| Medicinal chemistry matters - a call for discipline in our discipline. | |
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MedLine Citation:
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PMID: 22301070 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Medicinal chemistry makes a vital contribution to small molecule drug discovery, and the quality of it contributes directly to research effectiveness as well as to downstream costs, speed and survival in development. In recent years, the discipline of medicinal chemistry has evolved and witnessed many noteworthy contributions that propose and offer potential improvements to medicinal chemistry practice; however, the impact of these ideas is limited by their acceptance and deployment into every-day activity and, as a result, the quality of medicinal chemistry remains variable. For the good of the industry and the medicinal chemistry discipline, there is a need to move from retrospective learning to prospective control of medicinal chemistry practice to improve cost effectiveness, probability of success and survival rates. |
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Authors:
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Craig Johnstone |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: Drug discovery today Volume: - ISSN: 1878-5832 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-2-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9604391 Medline TA: Drug Discov Today Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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AstraZeneca Pharmaceuticals, Cardiovascular and Gastrointestinal Research, Mereside, Alderley Park, Alderley Edge, Cheshire SK10 4TG, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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