| Medicinal chemistry for 2020. | |
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MedLine Citation:
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PMID: 22004084 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Rapid advances in our collective understanding of biomolecular structure and, in concert, of biochemical systems, coupled with developments in computational methods, have massively impacted the field of medicinal chemistry over the past two decades, with even greater changes appearing on the horizon. In this perspective, we endeavor to profile some of the most prominent determinants of change and speculate as to further evolution that may consequently occur during the next decade. The five main angles to be addressed are: protein-protein interactions; peptides and peptidomimetics; molecular diversity and pharmacological space; molecular pharmacodynamics (significance, potential and challenges); and early-stage clinical efficacy and safety. We then consider, in light of these, the future of medicinal chemistry and the educational preparation that will be required for future medicinal chemists. |
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Authors:
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Seetharama D Satyanarayanajois; Ronald A Hill |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Future medicinal chemistry Volume: 3 ISSN: 1756-8927 ISO Abbreviation: Future Med Chem Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101511162 Medline TA: Future Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 1765-86 Citation Subset: IM |
Affiliation:
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Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe LA 71201, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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