Document Detail

Medications used in the treatment of hypoglycemia due to congenital hyperinsulinism of infancy (HI).
MedLine Citation:
PMID:  16456495     Owner:  NLM     Status:  MEDLINE    
Congenital hyperinsulinism of infancy is the commonest cause of persistent and recurrent hypoglycaemia in the neonatal and infancy period. It is a heterogeneous disorder with respect to clinical presentation, histology, molecular biology and genetics. The biochemical profile is one of hypoketotic, hypofattyacidemic hypoglycemia. To prevent permanent brain damage from hypoglycemia, the treatment of infants with congenital hyperinsulinism must be prompt and aggressive. The drugs used in the medical therapy for congenital hyperinsulinism are diazoxide, octreotide, glucagon and nifedipine.
Khalid Hussain; Albert Aynsley-Green; Charles A Stanley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Pediatric endocrinology reviews : PER     Volume:  2 Suppl 1     ISSN:  1565-4753     ISO Abbreviation:  Pediatr Endocrinol Rev     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2006-02-03     Completed Date:  2006-02-27     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  101202124     Medline TA:  Pediatr Endocrinol Rev     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  163-7     Citation Subset:  IM    
The London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust WC1N 3JH and the Institute of Child Health, University College London, WC1N 1EH United Kingdom.
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MeSH Terms
Diazoxide / therapeutic use
Gastrointestinal Agents / therapeutic use*
Glucagon / therapeutic use
Hypoglycemia / congenital,  drug therapy*
Nifedipine / therapeutic use
Octreotide / therapeutic use*
Persistent Hyperinsulinemia Hypoglycemia of Infancy / drug therapy*
Vasodilator Agents / therapeutic use
Reg. No./Substance:
0/Gastrointestinal Agents; 0/Vasodilator Agents; 21829-25-4/Nifedipine; 364-98-7/Diazoxide; 83150-76-9/Octreotide; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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