| Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review. | |
| | |
MedLine Citation:
|
PMID: 20701405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect and one of the most common genetic disorders worldwide, with an estimated 400 million people worldwide carrying a mutation in the G6PD gene that causes deficiency of the enzyme. Although drug-induced haemolysis is considered the most common adverse clinical consequence of G6PD deficiency, significant confusion exists regarding which drugs can cause haemolytic anaemia in patients with G6PD deficiency. In the absence of consensus among physicians, patients are subject to conflicting advice, causing uncertainty and distress. In the current review we aimed, by thorough search of the medical literature, to collect evidence on which to base decisions either to prohibit or allow the use of various medications in patients with G6PD deficiency. A literature search was conducted during May 2009 for studies and case reports on medication use and G6PD deficiency using the following sources: MEDLINE (1966-May 2009), PubMed (1950-May 2009), the Cochrane database of systematic reviews (2009), and major pharmacology, internal medicine, haematology and paediatric textbooks. After assessing the literature, we divided medications into one of three groups: medications that should be avoided in individuals with G6PD deficiency, medications that were considered unsafe by at least one source, but according to our review can probably be given safely in normal therapeutic dosages to individuals with G6PD deficiency as evidence does not contravene their use, and medications where no evidence at all was found to contravene their use in G6PD-deficient patients. It is reasonable to conclude that, over time, many compounds have been wrongly cited as causing haemolysis because they were administered to patients experiencing an infection-related haemolytic episode. We found solid evidence to prohibit only seven currently used medications: dapsone, methylthioninium chloride (methylene blue), nitrofurantoin, phenazopyridine, primaquine, rasburicase and tolonium chloride (toluidine blue). Regarding all other medications, our review found no evidence to contravene their use in normal therapeutic doses to G6PD-deficient patients. There is a need for evidence-based global consensus regarding medication use in G6PD-deficient patients. |
| | |
Authors:
|
Ilan Youngster; Lidia Arcavi; Renata Schechmaster; Yulia Akayzen; Hen Popliski; Janna Shimonov; Svetlana Beig; Matitiahu Berkovitch |
Related Documents
:
|
7594275 - Upper extremity disorders: a literature review to determine work-relatedness. 21961425 - The nervous system: conditions involving the nervous system can present in many differe... 18349625 - Reduction mammaplasty: a review of managed care medical policy coverage criteria. 10353575 - How to write about pollen. 3725005 - Recognition and management of antidepressant overdoses: tricyclics and trazodone. 19929235 - Online consultations in cyberpharmacies: completeness and patient safety. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Drug safety : an international journal of medical toxicology and drug experience Volume: 33 ISSN: 0114-5916 ISO Abbreviation: Drug Saf Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-12 Completed Date: 2010-11-22 Revised Date: 2012-01-19 |
Medline Journal Info:
|
Nlm Unique ID: 9002928 Medline TA: Drug Saf Country: New Zealand |
Other Details:
|
Languages: eng Pagination: 713-26 Citation Subset: IM |
Affiliation:
|
Clinical Pharmacology Unit, Assaf Harofeh Medical Center, Zerifin, Israel. ilanyoungster@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anemia, Hemolytic
/
chemically induced*,
etiology Animals Evidence-Based Medicine Glucosephosphate Dehydrogenase Deficiency / complications* Hemolysis / drug effects Humans Pharmaceutical Preparations / administration & dosage, adverse effects*, contraindications |
| Chemical | |
Reg. No./Substance:
|
0/Pharmaceutical Preparations |
| Comments/Corrections | |
Comment In:
|
Drug Saf. 2012 Jan 1;35(1):85; author reply 85-6
[PMID:
22149420
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tramadol/paracetamol fixed-dose combination: a review of its use in the management of moderate to se...
Next Document: Lactic acidosis induced by metformin: incidence, management and prevention.