| Medications acting on the dopaminergic system in the treatment of alcoholic patients. | |
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MedLine Citation:
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PMID: 20482513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An extensive literature supports the role of dopamine in the development and maintenance of alcohol dependence. Yet the organization of brain dopamine is complex, with multiple dopamine receptor subtypes and distinct effects on reinforcement, craving, motivation and behavior. Several modestly effective pharmacological treatments for alcoholism, including naltrexone, baclofen and ondansetron, affect dopaminergic systems indirectly. Direct dopamine antagonists, including tiapride, quetiapine, ondansetron and clozapine have been shown to be somewhat effective in reducing alcohol consumption in controlled clinical trials. The partial dopamine agonist, aripiprazole has shown mixed efficacy. Dopaminergic medications can have significant side effects. A better understanding of how dopamine affects the various aspects of addictive behavior may lead to more effective medications. |
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Authors:
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Robert Swift |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current pharmaceutical design Volume: 16 ISSN: 1873-4286 ISO Abbreviation: Curr. Pharm. Des. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-06 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602487 Medline TA: Curr Pharm Des Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2136-40 Citation Subset: IM |
Affiliation:
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Brown University Center for Alcohol and Addiction Studies, 121 South Main Street, Room 404, Providence, RI 02903, USA. Robert_Swift@brown.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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prevention & control Alcoholism / drug therapy*, physiopathology Animals Behavior, Addictive / drug therapy Brain / metabolism Controlled Clinical Trials as Topic Dopamine / metabolism* Dopamine Agents / adverse effects, pharmacology, therapeutic use* Dopamine Antagonists / adverse effects, pharmacology, therapeutic use Humans Receptors, Dopamine / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agents; 0/Dopamine Antagonists; 0/Receptors, Dopamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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