Document Detail


Medication use during pregnancy and the risk of childhood cancer in the offspring.
MedLine Citation:
PMID:  17345098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The young age at onset of many cancers in childhood has led to investigations on maternal exposures during pregnancy. Data from a population-based case-control study in Germany (1992-1997) that included 1,867 cases and 2,057 controls was used to investigate this question. Maternal use of vitamin, folate or iron supplementation was associated with a reduced risk of non-Hodgkin lymphoma and tumors and, less clearly, with leukemia, but not with CNS tumors. An increased risk of neuroblastoma was associated most markedly with diuretics and other antihypertensives, but also with vitamin, folate or iron supplementation. No associations were seen with pain relievers, antinauseants or cold medications, nor with delivery by Caesarian section. The strengths of this study are its population base, the large number of cases and the inclusion of different case groups to identify disease specificity of associations. The limitation of this study is an exposure assessment relying on maternal self-reports. In conclusion, these data indicate a potential influence of some maternal medication during pregnancy on the risk of childhood cancer in the offspring; however, no clear picture is seen.
Authors:
Joachim Schüz; Thomas Weihkopf; Peter Kaatsch
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Publication Detail:
Type:  Journal Article     Date:  2007-03-08
Journal Detail:
Title:  European journal of pediatrics     Volume:  166     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-03-20     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  433-41     Citation Subset:  IM    
Affiliation:
Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Johannes Gutenberg-University of Mainz, 55101, Mainz, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Age of Onset
Case-Control Studies
Child
Child, Preschool
Female
Germany / epidemiology
Humans
Infant
Infant, Newborn
Logistic Models
Male
Maternal Exposure
Maternal-Fetal Exchange
Neoplasms / chemically induced*,  epidemiology
Pharmaceutical Preparations / adverse effects*
Pregnancy
Prenatal Exposure Delayed Effects*
Risk Factors
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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