| Medication use as a risk factor for inpatient falls in an acute care hospital: a case-crossover study. | |
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MedLine Citation:
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PMID: 20573090 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The present study aimed to evaluate the associations between medication use and falls and to identify high risk medications that acted as a trigger for the onset of falls in an acute care hospital setting. METHODS: We applied a case-crossover design wherein cases served as their own controls and comparisons were made within each participant. The 3-day period (days 0 to -2) and the 3-day periods (days -6 to -8, days -9 to -11 and days -12 to -14) before the fall event were defined as the case period and the control periods, respectively. Exposures to medications were compared between the case and control periods. Odds ratios (OR) and 95% confidence intervals (CI) for the onset of falls with respect to medication use were computed using conditional logistic regression analyses. RESULTS: A total of 349 inpatients who fell during their hospitalization were recorded on incident report forms between March 2003 and August 2005. The initial use of antihypertensive, antiparkinsonian, anti-anxiety and hypnotic agents as medication classes was significantly associated with an increased risk of falls, and these ORs (95% CI) were 8.42 (3.12, 22.72), 4.18 (1.75, 10.02), 3.25 (1.62, 6.50) and 2.44 (1.32, 4.51), respectively. The initial use of candesartan, etizolam, biperiden and zopiclone was also identified as a potential risk factor for falls. CONCLUSIONS: Medical professionals should be aware of the possibility that starting a new medication such as an antihypertensive agent, including candesartan, and antiparkinsonian, anti-anxiety and hypnotic agents, may act as a trigger for the onset of a fall. |
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Authors:
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Hideki Shuto; Osamu Imakyure; Junichi Matsumoto; Takashi Egawa; Ying Jiang; Masaaki Hirakawa; Yasufumi Kataoka; Takashi Yanagawa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 69 ISSN: 1365-2125 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-24 Completed Date: 2011-03-28 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 535-42 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. shuto@fukuoka-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Accidental Falls
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statistics & numerical data* Adult Aged Aged, 80 and over Critical Care Cross-Over Studies Female Hospitalization / statistics & numerical data* Humans Inpatients / statistics & numerical data* Male Middle Aged Pharmaceutical Preparations / adverse effects* Risk Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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