Document Detail

Medication response to ECT-resistant melancholic patients.
MedLine Citation:
PMID:  8525854     Owner:  NLM     Status:  MEDLINE    
During an ongoing study on potential neurochemical and neuroendocrine predictors of recovery after ECT, it was observed that depressed patients with unfavorable response to ECT, improved consequently with antidepressants alone or in combination and in some cases with the addition of neuroleptics or lithium salts. 13 female depressed patients with melancholia (DSM-III criteria), who had proven resistant to electroconvulsive therapy (ECT) and showed marked improvement with subsequent psychopharmacologic regimens, are described. In not less than 2 months after the last ECT, remission was achieved with a heterocyclic antidepressant (HCA) alone (3 patients) combined infusion of chlorimipramine and maprotiline (3 patients) combined HCAs-antipsychotics (4 patients) and HCAs in combination with lithium (3 patients). It is worth noting that certain depressed patients improved markedly with drugs which had poor results at the same doses before ECT. Confirmation of these observations by prospective studies would provide novel therapeutic capabilities and clues about the mode of action of this controversial treatment.
L Lykouras; D Avgoustides; Y Papakostas; C Stefanis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta psychiatrica Belgica     Volume:  95     ISSN:  0300-8967     ISO Abbreviation:  Acta Psychiatr Belg     Publication Date:    1995 May-Jun
Date Detail:
Created Date:  1996-01-25     Completed Date:  1996-01-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247037     Medline TA:  Acta Psychiatr Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  113-21     Citation Subset:  IM    
Department of Psychiatry, Athens University Medical School, Eginition Hospital, Greece.
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MeSH Terms
Antidepressive Agents / administration & dosage,  therapeutic use*
Depressive Disorder / drug therapy*,  therapy
Drug Therapy, Combination
Electroconvulsive Therapy*
Middle Aged
Treatment Outcome
Reg. No./Substance:
0/Antidepressive Agents

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