Document Detail

Medication-induced esophageal injury: report of 17 cases with endoscopic documentation.
MedLine Citation:
PMID:  2038999     Owner:  NLM     Status:  MEDLINE    
We report on medication-induced esophageal injury (MIEI) in 17 patients (six male, 11 female) seen from October 1986 to May 1990. The mean age of patients was 27.3 (SD = 5.7) yr; mean duration of drug ingestion prior to the occurrence of symptoms 10.2 (SD = 11.5) days, and mean duration of symptoms before seeking medical attention 4.6 (SD = 3.8) days. Symptoms subsided after treatment, with a mean of 6 (SD = 2.5) days. Symptoms included odynophagia (in 17), chest pain (six), epigastric pain (three), and retrosternal pain (one). Symptoms occurred after the drug was stopped in three. MIEI was caused by doxycycline (seven), minocycline (five), Pantozyme (one), cloxacillin (one), unknown (two), and dicloxacillin + Danzen (one). Reclining after drug ingestion was the predominant risk factor. Endoscopy showed most ulcers to be multiple and at midesophagus. Barium swallows done in two patients were negative. There is no previous report of Pantozyme (pancreatic enzyme), Danzen (serratio-peptidase), cloxacillin, and dicloxacillin causing MIEI.
B Ovartlarnporn; W Kulwichit; S Hiranniramol
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  86     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-03     Completed Date:  1991-07-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  748-50     Citation Subset:  IM    
Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat-yai, Thailand.
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MeSH Terms
Anti-Bacterial Agents / adverse effects*
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Esophageal Diseases / chemically induced*,  pathology
Esophagus / pathology
Pancreatic Extracts / adverse effects*
Peptide Hydrolases / adverse effects*
Ulcer / chemically induced,  pathology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Pancreatic Extracts; EC 3.4.-/Peptide Hydrolases; EC 3.4.-/serratiopeptidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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