| Medication improves balance and complex gait performance in Parkinson disease. | |
| | |
MedLine Citation:
|
PMID: 22418585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Gait and balance impairments in people with Parkinson disease (PD) may lead to falls and serious injuries. Therefore, it is critical to improve our understanding of the nature of these impairments, including how they respond to prescribed anti-Parkinson medication. This is particularly important for complex balance and gait tasks that may be associated with falls. We evaluated motor function, functional balance, and gait performance during various gait tasks in 22 people with PD OFF and ON medication (PD OFF, PD ON) and 20 healthy older adults. Although MDS-UPDRS-III score, Berg Balance Scale, Mini-Balance Evaluations Systems test, and Timed-Up-and-Go improved in PD with medication, impairments persisted in all measures on medication, compared to controls. Dual task Timed-Up-and-Go did not improve with medication, and PD ON required more time than controls. Gait velocity and stride length improved similarly with medication in PD across forward, fast, backward, dual task forward, and dual task backward gait tasks. Cadence did not change with medication, nor did it differ between PD ON and controls. Velocity and stride length were reduced in PD ON compared to controls. Velocity reductions in PD ON during fast gait were cadence-mediated, while velocity reductions in backward gait were stride length-mediated. Our results suggest functional balance improves with medication in PD and gait performance improves with medication, regardless of task complexity. Remaining impairments on medication highlight the need to examine additional therapeutic options for individuals with PD to reduce the risk of falls. |
| | |
Authors:
|
Marie E McNeely; Ryan P Duncan; Gammon M Earhart |
Related Documents
:
|
342295 - Comparative blanching activities of proprietary diflucortolone valerate topical prepara... 16469415 - Investigation on recombinant hirudin via oral route. 1246375 - Progestational potency of oral contraceptives. 12012745 - Oral medications. 21037395 - Presidential address: the origins and evolution of the mayo clinic from 1864 to 1939: a... 9287455 - Validity of clinical information from a maternity survey. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-03-13 |
Journal Detail:
|
Title: Gait & posture Volume: 36 ISSN: 1879-2219 ISO Abbreviation: Gait Posture Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-06-11 Completed Date: 2012-10-29 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 9416830 Medline TA: Gait Posture Country: England |
Other Details:
|
Languages: eng Pagination: 144-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
|
Program in Physical Therapy, Washington University in St. Louis, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Accidental Falls
/
prevention & control Aged Analysis of Variance Antiparkinson Agents / administration & dosage* Case-Control Studies Female Follow-Up Studies Gait / drug effects*, physiology* Gait Disorders, Neurologic / drug therapy, etiology, rehabilitation Humans Male Middle Aged Parkinson Disease / complications, drug therapy*, rehabilitation Postural Balance / drug effects*, physiology Psychomotor Performance / drug effects, physiology Reference Values Risk Assessment Severity of Illness Index Task Performance and Analysis Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
|
F31 NS071639/NS/NINDS NIH HHS; F31 NS071639-02/NS/NINDS NIH HHS; F31 NS071639-03/NS/NINDS NIH HHS; R01 HD056015/HD/NICHD NIH HHS; R01 HD056015-01A2/HD/NICHD NIH HHS; R01 HD056015-02/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antiparkinson Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Community-dwelling people with chronic stroke need disproportionate attention while walking and nego...
Next Document: Exposure to ambient air fine particulate matter prevents VEGF-induced mobilization of endothelial pr...