Document Detail

Medication improves balance and complex gait performance in Parkinson disease.
MedLine Citation:
PMID:  22418585     Owner:  NLM     Status:  MEDLINE    
Gait and balance impairments in people with Parkinson disease (PD) may lead to falls and serious injuries. Therefore, it is critical to improve our understanding of the nature of these impairments, including how they respond to prescribed anti-Parkinson medication. This is particularly important for complex balance and gait tasks that may be associated with falls. We evaluated motor function, functional balance, and gait performance during various gait tasks in 22 people with PD OFF and ON medication (PD OFF, PD ON) and 20 healthy older adults. Although MDS-UPDRS-III score, Berg Balance Scale, Mini-Balance Evaluations Systems test, and Timed-Up-and-Go improved in PD with medication, impairments persisted in all measures on medication, compared to controls. Dual task Timed-Up-and-Go did not improve with medication, and PD ON required more time than controls. Gait velocity and stride length improved similarly with medication in PD across forward, fast, backward, dual task forward, and dual task backward gait tasks. Cadence did not change with medication, nor did it differ between PD ON and controls. Velocity and stride length were reduced in PD ON compared to controls. Velocity reductions in PD ON during fast gait were cadence-mediated, while velocity reductions in backward gait were stride length-mediated. Our results suggest functional balance improves with medication in PD and gait performance improves with medication, regardless of task complexity. Remaining impairments on medication highlight the need to examine additional therapeutic options for individuals with PD to reduce the risk of falls.
Marie E McNeely; Ryan P Duncan; Gammon M Earhart
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-03-13
Journal Detail:
Title:  Gait & posture     Volume:  36     ISSN:  1879-2219     ISO Abbreviation:  Gait Posture     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-10-29     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  9416830     Medline TA:  Gait Posture     Country:  England    
Other Details:
Languages:  eng     Pagination:  144-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Accidental Falls / prevention & control
Analysis of Variance
Antiparkinson Agents / administration & dosage*
Case-Control Studies
Follow-Up Studies
Gait / drug effects*,  physiology*
Gait Disorders, Neurologic / drug therapy,  etiology,  rehabilitation
Middle Aged
Parkinson Disease / complications,  drug therapy*,  rehabilitation
Postural Balance / drug effects*,  physiology
Psychomotor Performance / drug effects,  physiology
Reference Values
Risk Assessment
Severity of Illness Index
Task Performance and Analysis
Treatment Outcome
Grant Support
F31 NS071639/NS/NINDS NIH HHS; F31 NS071639-02/NS/NINDS NIH HHS; F31 NS071639-03/NS/NINDS NIH HHS; R01 HD056015/HD/NICHD NIH HHS; R01 HD056015/HD/NICHD NIH HHS; R01 HD056015-01A2/HD/NICHD NIH HHS; R01 HD056015-02/HD/NICHD NIH HHS
Reg. No./Substance:
0/Antiparkinson Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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