| Medication errors involving oral chemotherapy. | |
| | |
MedLine Citation:
|
PMID: 20225328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Given the expanding use of oral chemotherapies, the authors set out to examine errors in the prescribing, dispensing, administration, and monitoring of these drugs. METHODS: Reports were collected of oral chemotherapy-associated medication errors from a medical literature and Internet search and review of reports to the Medication Errors Reporting Program and MEDMARX. The authors solicited incident reports from 14 comprehensive cancer centers, and also collected incident reports, pharmacy interventions, and prompted clinician reports from their own center. They classified the type of incident, severity, stage in the medication use process, and type of medication error. They examined the yield of the various reporting methods to identify oral chemotherapy-related medication errors. RESULTS: The authors identified 99 adverse drug events, 322 near misses, and 87 medical errors with low risk of harm. Of the 99 adverse drug events, 20 were serious or life-threatening, 52 were significant, and 25 were minor. The most common medication errors involved wrong dose (38.8%), wrong drug (13.6%), wrong number of days supplied (11.0%), and missed dose (10.0%). The majority of errors resulted in a near miss; however, 39.3% of reports involving the wrong number of days supplied resulted in adverse drug events. Incidents derived from the literature search and hospital incident reporting system included a larger percentage of adverse drug events (73.1% and 58.8%, respectively) compared with other sources. CONCLUSIONS: Ensuring oral chemotherapy safety requires improvements in the way these drugs are ordered, dispensed, administered, and monitored. |
| | |
Authors:
|
Saul N Weingart; Julio Toro; Justin Spencer; Deborah Duncombe; Anne Gross; Sylvia Bartel; Jeremy Miransky; Ann Partridge; Lawrence N Shulman; Maureen Connor |
Related Documents
:
|
19002338 - Prevention of polymorphic light eruption with a sunscreen of very high protection level... 19417218 - Improving medication error reporting in hospice care. 11008438 - Medication error reporting: a survey of nursing staff. 17245198 - The effect of the fit between organizational culture and structure on medication errors... 17519188 - Floral reward production is timed by an insect pollinator. 10266568 - An introduction to the clinical laboratory for pharmacists. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Cancer Volume: 116 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-04 Completed Date: 2010-05-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
|
Languages: eng Pagination: 2455-64 Citation Subset: AIM; IM |
Copyright Information:
|
(c) 2010 American Cancer Society. |
Affiliation:
|
Center for Patient Safety, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. saul_weingart@dfci.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral* Adverse Drug Reaction Reporting Systems Antineoplastic Agents / administration & dosage* Drug Monitoring Drug Toxicity Humans Incidence Medication Errors / statistics & numerical data* Prescriptions |
| Grant Support | |
ID/Acronym/Agency:
|
P20 HS17123-01/HS/AHRQ HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phase 2 study of carboplatin, docetaxel, and bevacizumab as frontline treatment for advanced nonsmal...
Next Document: Weekly alternating therapy with irinotecan plus cisplatin and etoposide plus cisplatin in the treatm...