| Medication dose reductions after pallidal versus subthalamic stimulation in patients with Parkinson's disease. | |
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MedLine Citation:
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PMID: 20969559 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Evidente VGH, Premkumar AP, Adler CH, Caviness JN, Driver-Dunckley E, Lyons MK. Medication dose reductions after pallidal versus subthalamic stimulation in patients with Parkinson's disease. Acta Neurol Scand: 2011: 124: 211-214. © 2010 John Wiley & Sons A/S. Objective - To compare the medication dose reduction between deep brain stimulation (DBS) of the globus pallidus interna (GPi) vs subthalamic nucleus (STN) in matched patients with Parkinson's disease (PD). Materials and methods - Records of 12 patients with PD who underwent GPi-DBS at our institution from 2002 to 2008 were matched by pre-operative PD medication doses and pre-operative motor Unified Parkinson's Disease Rating Scale (UPDRS) scores to 12 cases of STN-DBS. PD medication doses were converted to levodopa equivalent doses (LEDs). Results - GPi and STN groups had similar mean pre-operative LEDs and motor UPDRS scores. At 6 months post-DBS, there was no significant difference in percent reduction in LEDs between the GPi (47.95%) and STN (37.47%) groups (P = 0.52). The mean post-operative 'medication off/stimulation on' motor UPDRS scores did not differ significantly between GPi (15.33) and STN (16.25) groups (P = 0.74). The mean percent reduction in motor UPDRS scores was also similar between GPi (58.44%) and STN (58.98%) patients (P = 0.94). Conclusions - We conclude that in disease-matched patients with PD undergoing DBS, both GPi and STN may result in similar reduction in PD medication doses. |
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Authors:
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V G H Evidente; A P Premkumar; C H Adler; J N Caviness; E Driver-Dunckley; M K Lyons |
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Publication Detail:
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Type: Journal Article Date: 2010-10-25 |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 124 ISSN: 1600-0404 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 211-4 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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Department of Neurology Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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