Document Detail


Medicating the environment: assessing risks of pharmaceuticals to wildlife and ecosystems.
MedLine Citation:
PMID:  25405959     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Global pharmaceutical consumption is rising with the growing and ageing human population and more intensive food production. Recent studies have revealed pharmaceutical residues in a wide range of ecosystems and organisms. Environmental concentrations are often low, but pharmaceuticals typically are designed to have biological effects at low doses, acting on physiological systems that can be evolutionarily conserved across taxa. This Theme Issue introduces the latest research investigating the risks of environmentally relevant concentrations of pharmaceuticals to vertebrate wildlife. We take a holistic, global view of environmental exposure to pharmaceuticals encompassing terrestrial, freshwater and marine ecosystems in high- and low-income countries. Based on both field and laboratory data, the evidence for and relevance of changes to physiology and behaviour, in addition to mortality and reproductive effects, are examined in terms of the population- and community-level consequences of pharmaceutical exposure on wildlife. Studies on uptake, trophic transfer and indirect effects of pharmaceuticals acting via food webs are presented. Given the logistical and ethical complexities of research in this area, several papers focus on techniques for prioritizing which compounds are most likely to harm wildlife and how modelling approaches can make predictions about the bioavailability, metabolism and toxicity of pharmaceuticals in non-target species. This Theme Issue aims to help clarify the uncertainties, highlight opportunities and inform ongoing scientific and policy debates on the impacts of pharmaceuticals in the environment.
Authors:
Kathryn E Arnold; A Ross Brown; Gerald T Ankley; John P Sumpter
Related Documents :
7361419 - A review of some animal diseases encountered at meat inspections in england and wales, ...
23799059 - Long-term stabilization effects of leptin on brain functions in a leptin-deficient pati...
25466669 - Differential modulation of endogenous cannabinoid cb1 and cb2 receptors in spontaneous ...
229 - Ecological observation of the 137cs-contamination in beef of animals from the southern-...
7373729 - Psoroptic scabies in bignorn sheep (ovis canadensis mexicana) in new mexico.
8525579 - Effects of the sucking louse (linognathus vituli) on the grooming behaviour of housed c...
19965359 - Gender-specific roles and needs in food-health security.
7790589 - Quantity and economic importance of nine selected by-products used in california dairy ...
16809639 - Taste receptors in the gastrointestinal tract iii. salty and sour taste: sensing of sod...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Philosophical transactions of the Royal Society of London. Series B, Biological sciences     Volume:  369     ISSN:  1471-2970     ISO Abbreviation:  Philos. Trans. R. Soc. Lond., B, Biol. Sci.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-18     Completed Date:  -     Revised Date:  2014-11-19    
Medline Journal Info:
Nlm Unique ID:  7503623     Medline TA:  Philos Trans R Soc Lond B Biol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 The Author(s) Published by the Royal Society. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Impact of losartan and angiotensin II on the expression of matrix metalloproteinase-9 and tissue inh...
Next Document:  Detection and drivers of exposure and effects of pharmaceuticals in higher vertebrates.