Document Detail

Medically refractory epilepsy associated with temporal lobe ganglioglioma: characteristics and postoperative outcome.
MedLine Citation:
PMID:  16318902     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To define the postoperative seizure outcome and its predictors in patients with ganglioglioma-related temporal lobe epilepsy (TLE). PATIENTS AND METHODS: We reviewed the pre- and post-surgical evaluation data of 23 patients with temporal lobe ganglioglioma, who had completed >or=1 year of postoperative follow-up. They comprised 4.9% of the patients with TLE and 67.6% of the tumoral TLE operated in a developing country epilepsy center during an 8-year period. RESULTS: Median age at surgery was 20 years; median duration of epilepsy prior to surgery was 9 years. Magnetic resonance imaging (MRI) revealed tumor in mesial temporal location in 18 patients (78.3%) and in the lateral location in 2; in the remaining 3, involved both mesial and lateral regions. EEG abnormalities were localized to the side of lesion in the majority. Mesial temporal lobe structures were included in the resection, if they were involved by the tumor; otherwise, lesionectomy alone was performed. During a median follow-up of 4 years, 19 (82.6%) patients were completely seizure-free. Epileptiform abnormalities persisting in the 1-year postoperative EEG predicted unfavorable seizure outcome. CONCLUSION: We emphasize that, in patients with temporal lobe ganglioglioma, when the seizures are medically refractory, surgery offers potential for cure of epilepsy in the majority.
Ashalatha Radhakrishnan; Mathew Abraham; Venkataraman V Radhakrishnan; Sankara P Sarma; Kurupath Radhakrishnan
Publication Detail:
Type:  Journal Article     Date:  2005-11-28
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  108     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2007-01-05     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  648-54     Citation Subset:  IM    
R. Madhavan Nayar Center for Comprehensive Epilepsy Care, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695 011, Kerala, India.
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MeSH Terms
Anticonvulsants / therapeutic use
Brain Neoplasms / complications*,  physiopathology,  surgery
Child, Preschool
Drug Resistance / physiology
Epilepsy / etiology*,  physiopathology,  surgery
Epilepsy, Temporal Lobe / etiology*,  physiopathology,  surgery
Ganglioglioma / complications*,  physiopathology,  surgery
Magnetic Resonance Imaging
Neurosurgical Procedures / methods,  statistics & numerical data
Predictive Value of Tests
Temporal Lobe / pathology*,  physiopathology*,  surgery
Treatment Outcome
Reg. No./Substance:

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