Document Detail

Medical treatment of transient ischemic attacks: does it influence mortality?
MedLine Citation:
PMID:  3354028     Owner:  NLM     Status:  MEDLINE    
All randomized studies published on the medical treatment of transient ischemic attacks in which controls received no treatment or placebo and in which mortality was reported were reviewed. Using the odds ratio method, we analyzed the results to determine if treatment had an effect on expected mortality. Studies were analyzed separately according to the treatment modality used. Chronic anticoagulation was used in four studies and platelet inhibitors in 12 (14 trials). This meta-analysis showed that neither treatment modality significantly reduces mortality. Chronic anticoagulation may have an adverse effect, and even though platelet inhibitors appeared to reduce mortality, no significance can be demonstrated, and the 95% confidence intervals did not allow us to rule out the possibility, albeit small, of an adverse effect or no effect at all.
M Ramirez-Lassepas; R J Cipolle
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  19     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-05-02     Completed Date:  1988-05-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  397-400     Citation Subset:  IM    
Department of Neurology, St. Paul-Ramsey Medical Center, MN 55101.
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MeSH Terms
Anticoagulants / therapeutic use
Aspirin / therapeutic use
Ischemic Attack, Transient / drug therapy*,  mortality
Platelet Aggregation Inhibitors / therapeutic use
Statistics as Topic
Time Factors
Reg. No./Substance:
0/Anticoagulants; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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