Document Detail

Medical treatment of ruptured with hemodynamically stable and unruptured ectopic pregnancy patients.
MedLine Citation:
PMID:  15358469     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the success rate of methotrexate treatment of ruptured ectopic pregnancy with hemodynamically stable and unruptured ectopic pregnancy patients. STUDY DESIGN: This prospective clinical study was carried out on 161 patients with suspected tubal ectopic pregnancy. Fourty-six patients have been accepted as ruptured ectopic pregnancy with hemodynamically stable and 115 patients have been accepted as unruptured ectopic pregnancy. All patients diagnosed with ectopic pregnancy were treated by single dose (50 mg/m2) methotrexate if they have stable hemodynamia and fulfill the criteria of methotrexate treatment. Weekly beta-hCG level was measured and if this level was under 10 IU/L, the treatment has been accepted as successful. Mann-Whitney and Fisher's exact tests were used (SPSS, 10.0) for statistical analysis. RESULTS: The success rates of methotrexate treatments in ruptured ectopic pregnancy patients with hemodynamically stable and in patients with unruptured ectopic pregnancy were observed as 62% and 81%, respectively (P < 0.001). The treatment was successfully completed in all expectant management patients. CONCLUSION: Although methotrexate treatment of ruptured ectopic pregnancy with hemodynamically stable patients is not as successful as in unruptured ectopic pregnancy group, 62% success rate in this group may promise a treatment choice before surgery application.
Yakup Kumtepe; Sedat Kadanali
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  116     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-10     Completed Date:  2005-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  221-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Faculty of Medicine, Ataturk University, 25200 Erzurum, Turkey.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage*
Blood Pressure
Chorionic Gonadotropin, beta Subunit, Human / blood
Heart Rate
Methotrexate / administration & dosage*
Pregnancy, Tubal / complications*,  drug therapy*,  physiopathology
Prospective Studies
Rupture, Spontaneous
Treatment Outcome
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Chorionic Gonadotropin, beta Subunit, Human; 59-05-2/Methotrexate

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