| Medical therapy in heart failure--is polypharmacy necessary? | |
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MedLine Citation:
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PMID: 15329755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The concept of heart failure has undergone several paradigm shifts in the past few decades. Therapeutic targets directed at the heart pump have shifted to circulatory haemodynamics to the current neurohormonal model. Consequently, therapeutic modalities have similarly evolved alongside clinical trials. Successive trials have tested newer drugs in addition to established therapies, resulting in evidence-based treatments necessitating polypharmacy. Optimal heart failure therapy has therefore become increasingly complex. It is only after understanding the precise modes of drug action, as well as the relevance of the design of clinical trials, will physicians hopefully be able to tailor the medical therapy optimally towards the individual patient with heart failure. |
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Authors:
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B W K Kwok |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the Academy of Medicine, Singapore Volume: 33 ISSN: 0304-4602 ISO Abbreviation: Ann. Acad. Med. Singap. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-08-26 Completed Date: 2004-11-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503289 Medline TA: Ann Acad Med Singapore Country: Singapore |
Other Details:
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Languages: eng Pagination: 444-50 Citation Subset: IM |
Affiliation:
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Department of Cardiology, National Heart Centre, 17 Third Hospital Avenue, Singapore 168752. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Aldosterone Antagonists / therapeutic use Algorithms Angiotensin-Converting Enzyme Inhibitors / therapeutic use Cardiotonic Agents / therapeutic use Heart Failure / drug therapy*, physiopathology Hemodynamics Humans Hydrazones / therapeutic use Polypharmacy* Pyridazines / therapeutic use Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Aldosterone Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Cardiotonic Agents; 0/Hydrazones; 0/Pyridazines; 131741-08-7/simendan |
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