Document Detail


Medical therapy of acute myocardial infarction: Part II. The role of adjunctive medical therapy.
MedLine Citation:
PMID:  10155176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The second part of this review summarizes the role of other classes of pharmacological therapy in treatment of acute myocardial infarction (MI). The goals of pharmacological therapy are to alleviate symptoms, to stabilize hemodynamic status, and to prevent arrhythmias. These agents have been utilized primarily because of their ability to limit infarct size. Other beneficial properties may include their effects on neurohormonal activation, hemodynamics, and arrhythmias. In an individual patient, age, associated medical conditions, and hemodynamic status are important considerations in choosing a specific class of drug therapy. The beta-adrenergic blocking agents have modest effects on mortality, and they are useful when used alone and in combination with thrombolytic agents. Calcium antagonists have a limited role in acute MI. Diltiazem reduces the incidence of reinfarction in patients with non-Q MI. Oral nitrate therapy has not been shown to reduce mortality. Data from recent trials suggest that prophylactic administration of antiarrhthymic therapy is also not useful in acute MI. The role of angiotensin-converting enzyme inhibitors when administered in the acute phase of MI needs to be evaluated further. These agents are safe and well tolerated, and they offer greatest benefit when given in patients with left ventricular dysfunction.
Authors:
S M Jafri; S Borzak
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of intensive care medicine     Volume:  10     ISSN:  0885-0666     ISO Abbreviation:  J Intensive Care Med     Publication Date:    1995 May-Jun
Date Detail:
Created Date:  1995-11-09     Completed Date:  1995-11-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8610344     Medline TA:  J Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-16     Citation Subset:  T    
Affiliation:
Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI 48202, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adrenergic beta-Antagonists / therapeutic use
Algorithms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Anti-Arrhythmia Agents / therapeutic use
Calcium Channel Blockers / therapeutic use
Cardiovascular Agents / therapeutic use*
Humans
Magnesium / therapeutic use
Myocardial Infarction / drug therapy*
Nitrates / therapeutic use
Thrombolytic Therapy
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Anti-Arrhythmia Agents; 0/Calcium Channel Blockers; 0/Cardiovascular Agents; 0/Nitrates; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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