| Medical and surgical treatment of chronic mitral regurgitation. | |
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MedLine Citation:
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PMID: 16645368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic severe mitral regurgitation is a progressive disease that can lead to left ventricular dysfunction. New information on the natural history of the disease, along with advances in surgical techniques, has changed the roles of medical and surgical therapies. There is no well-defined role for medical therapy in chronic mitral regurgitation. The goal of the treating physician is therefore to identify the optimal timing for surgical intervention. The timing of surgical intervention depends primarily on two factors: (i) clinical symptoms and (ii) the left ventricular response to volume overload. However, the aetiology of mitral regurgitation, the likelihood of surgical repair, the occurrence of atrial fibrillation and the presence of pulmonary hypertension, together with the haemodynamic response to exercise, are important factors in the optimal surgical timing. New concepts in the understanding of the natural history of the disease coupled with success of mitral repair have recently resulted in a widespread evolution towards earlier surgery. |
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Authors:
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Fabio Chirillo; Loris Salvador; Claudio Cavallini |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of cardiovascular medicine (Hagerstown, Md.) Volume: 7 ISSN: 1558-2027 ISO Abbreviation: J Cardiovasc Med (Hagerstown) Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-05-03 Completed Date: 2006-05-25 Revised Date: 2009-05-28 |
Medline Journal Info:
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Nlm Unique ID: 101259752 Medline TA: J Cardiovasc Med (Hagerstown) Country: United States |
Other Details:
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Languages: eng Pagination: 96-107 Citation Subset: IM |
Affiliation:
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Cardiology Unit, Cardiovascular Department, Ca' Foncello Hospital, Treviso, Italy. fchirillo@ulss.tv.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiomyopathy, Dilated
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surgery Chronic Disease Comorbidity Echocardiography, Doppler Echocardiography, Transesophageal Heart Valve Prosthesis Implantation Hemodynamics / drug effects Mitral Valve / surgery Mitral Valve Insufficiency / drug therapy*, epidemiology, physiopathology, surgery* Stroke Volume Treatment Outcome Vasodilator Agents / pharmacology, therapeutic use* Ventricular Dysfunction, Left / epidemiology Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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