Document Detail

Medical and surgical treatment of chronic mitral regurgitation.
MedLine Citation:
PMID:  16645368     Owner:  NLM     Status:  MEDLINE    
Chronic severe mitral regurgitation is a progressive disease that can lead to left ventricular dysfunction. New information on the natural history of the disease, along with advances in surgical techniques, has changed the roles of medical and surgical therapies. There is no well-defined role for medical therapy in chronic mitral regurgitation. The goal of the treating physician is therefore to identify the optimal timing for surgical intervention. The timing of surgical intervention depends primarily on two factors: (i) clinical symptoms and (ii) the left ventricular response to volume overload. However, the aetiology of mitral regurgitation, the likelihood of surgical repair, the occurrence of atrial fibrillation and the presence of pulmonary hypertension, together with the haemodynamic response to exercise, are important factors in the optimal surgical timing. New concepts in the understanding of the natural history of the disease coupled with success of mitral repair have recently resulted in a widespread evolution towards earlier surgery.
Fabio Chirillo; Loris Salvador; Claudio Cavallini
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  7     ISSN:  1558-2027     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-05-03     Completed Date:  2006-05-25     Revised Date:  2009-05-28    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-107     Citation Subset:  IM    
Cardiology Unit, Cardiovascular Department, Ca' Foncello Hospital, Treviso, Italy.
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MeSH Terms
Cardiomyopathy, Dilated / surgery
Chronic Disease
Echocardiography, Doppler
Echocardiography, Transesophageal
Heart Valve Prosthesis Implantation
Hemodynamics / drug effects
Mitral Valve / surgery
Mitral Valve Insufficiency / drug therapy*,  epidemiology,  physiopathology,  surgery*
Stroke Volume
Treatment Outcome
Vasodilator Agents / pharmacology,  therapeutic use*
Ventricular Dysfunction, Left / epidemiology
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Vasodilator Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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