Document Detail


Medical and surgical therapy of the cystine stone patient.
MedLine Citation:
PMID:  11429493     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cystinuria is an inherited defect in renal tubular and intestinal transport of dibasic amino acids that results in elevated urinary excretion of cystine, ornithine, lysine, and arginine. The only clinical manifestation of this disease is the development of urinary tract cystine calculi. Cystinuric patients suffer recurrent stone episodes, requiring an aggressive multi-modal approach to management. This article reviews the results of medical prevention regimens, the role of minimally invasive urologic intervention, and the recent insights into the complex genetic basis for the varied cystinuric phenotypes.
Authors:
C S Ng; S B Streem
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in urology     Volume:  11     ISSN:  0963-0643     ISO Abbreviation:  Curr Opin Urol     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-28     Completed Date:  2001-12-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9200621     Medline TA:  Curr Opin Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-8     Citation Subset:  IM    
Affiliation:
Cleveland Clinic Urological Institute, Cleveland, Ohio 44195, USA.
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MeSH Terms
Descriptor/Qualifier:
Cystine* / analysis
Genotype
Humans
Lithotripsy
Nephrostomy, Percutaneous
Phenotype
Ureteroscopy
Urinary Calculi / chemistry,  genetics,  therapy*
Chemical
Reg. No./Substance:
56-89-3/Cystine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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