Document Detail

Medical management of thyroid dysfunction in pregnancy and the postpartum.
MedLine Citation:
PMID:  18710353     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Uncontrolled thyroid dysfunction in pregnancy is associated with adverse fetal and maternal outcomes. OBJECTIVES: To review relevant literature and developments in the medical management of thyroid dysfunction in pregnancy. RESULTS: Hyperthyroidism in pregnancy requires careful control of maternal disease whilst avoiding fetal hypothyroidism. Propylthiouracil is the preferred antithyroid drug in pregnancy although thiamazole can be used where propylthiouracil is unavailable. Synthetic levothyroxine is the treatment of choice in hypothyroidism. Patients with pre-existing hypothyroidism will generally require an increase in thyroxine dose in pregnancy. Most patients with postpartum thyroiditis will require treatment during the hypothyroid phase. Long-term follow-up of patients with this syndrome is essential owing to the risk of permanent hypothyroidism. CONCLUSION: Excellent maternal and fetal outcomes can be achieved with appropriate management of thyroid dysfunction in pregnancy.
Onyebuchi E Okosieme; Helen Marx; John H Lazarus
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  9     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-19     Completed Date:  2008-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  2281-93     Citation Subset:  IM    
Prince Charles Hospital, Department of Endocrinology and Diabetes, Cwm Taff NHS Trust Merthyr Tydfil, Mid Glamorgan CF479DT, UK.
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MeSH Terms
Antithyroid Agents / therapeutic use
Breast Feeding
Graves Disease / drug therapy
Hyperthyroidism / drug therapy*,  physiopathology
Hypothyroidism / drug therapy*,  physiopathology
Pregnancy Complications / drug therapy*,  physiopathology
Pregnancy Outcome
Puerperal Disorders / drug therapy,  physiopathology
Thyroid Gland / physiopathology
Thyroid Hormones / therapeutic use
Reg. No./Substance:
0/Antithyroid Agents; 0/Thyroid Hormones

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