Document Detail

Medical management of bleeding esophageal varices.
MedLine Citation:
PMID:  1362377     Owner:  NLM     Status:  MEDLINE    
Vasoactive drug therapy is the only therapy that can be administered immediately to patients with suspected variceal bleeding. The optimal agent is not yet available, but somatostatin or octreotide, glypressin and vasopressin and nitroglycerin are the best candidates. Somatostatin and octreotide have the best therapeutic index as they have very few side effects. They compare well to the other agents in comparative randomized trials. In addition to being used prior to sclerotherapy, vasoactive agents may show benefit when used in combination with endoscopic methods and in the immediate interval thereafter in order to prevent early re-bleeding. This remains to be tested in clinical trials.
A K Burroughs
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Review    
Journal Detail:
Title:  Digestive diseases (Basel, Switzerland)     Volume:  10 Suppl 1     ISSN:  0257-2753     ISO Abbreviation:  Dig Dis     Publication Date:  1992  
Date Detail:
Created Date:  1993-02-16     Completed Date:  1993-02-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8701186     Medline TA:  Dig Dis     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  30-7     Citation Subset:  IM    
University Department of Medicine, Royal Free Hospital and School of Medicine, London, UK.
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MeSH Terms
Drug Therapy, Combination
Esophageal and Gastric Varices / drug therapy*
Gastrointestinal Hemorrhage / drug therapy*
Octreotide / administration & dosage,  therapeutic use
Somatostatin / administration & dosage,  therapeutic use
Vasoconstrictor Agents / therapeutic use
Reg. No./Substance:
0/Vasoconstrictor Agents; 51110-01-1/Somatostatin; 83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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