| Medical management of ascites. | |
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MedLine Citation:
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PMID: 21306283 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Ascites is a common complication of advanced cirrhosis that has a significant negative impact on survival. This review updates the reader on the medical management of ascites. Areas covered: This review explores the pathophysiology of ascites formation in cirrhosis; the current mainstays of medical management (treating the underlying cause of cirrhosis, avoiding nephrotoxic agents, sodium restriction, and combination diuretic therapy); potential novel agents, such as vasoconstrictors and vaptans; and albumin infusions. The literature research covers all aspects of medical management of ascites from the English literature, concentrating on publications from the past 10 years. It provides a thorough understanding of how the correction of pathophysiology of ascites formation helps to improve ascites; knowledge on the monitoring of patients with cirrhosis and ascites receiving medical management, and on prophylaxis against potentially life-threatening complication such as spontaneous bacterial peritonitis; and potential new treatments for ascites. Expert opinion: Management of patients with cirrhosis and ascites requires careful attention to fluid and electrolyte balance and avoidance of complications. Recognition of refractory ascites allows for the use of second-line treatments. All patients with cirrhosis and ascites should be considered for liver transplantation. |
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Authors:
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Wesley Leung; Florence Wong |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-10 |
Journal Detail:
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Title: Expert opinion on pharmacotherapy Volume: - ISSN: 1744-7666 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Toronto, Toronto General Hospital, Department of Medicine, 9N/983, 200 Elizabeth Street, Toronto, Ontario M5G2C4, Canada +416 340 3834 ; +416 340 5019 ; florence.wong@utoronto.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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