Document Detail

Medical management of aldosterone-producing adenomas.
MedLine Citation:
PMID:  10419425     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: No data are available on the long-term medical management of aldosterone-producing adenomas. OBJECTIVE: To demonstrate the efficacy of medical management of aldosterone-producing adenomas in terms of blood pressure and serum potassium concentration and to discuss morbidity associated with medical management. DESIGN: Retrospective cohort study. SETTING: Large tertiary care referral center. PATIENTS: 24 patients with documented aldosterone-producing adenomas who were treated medically for at least 5 years. MEASUREMENTS: Aldosterone excretion rate, plasma renin activity, and size and location of adenomas (by computed tomography). Blood pressure and serum electrolytes were measured at the time of diagnosis and last follow-up. RESULTS: From the time of diagnosis to the time of last follow-up, systolic blood pressure decreased from 175 mm Hg to 129 mm Hg (95% CI for difference, 37.1 to 53.8 mm Hg) and diastolic blood pressure decreased from 106 mm Hg to 79 mm Hg (CI for difference, 20.8 to 33.9 mm Hg). Serum potassium concentration increased from 3.0 mmol/L to 4.3 mmol/L (CI for difference, 1.1 to 1.5 mmol/L). CONCLUSIONS: Medical management of aldosterone-producing adenomas is a viable option for controlling blood pressure and serum potassium concentration.
R P Ghose; P M Hall; E L Bravo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of internal medicine     Volume:  131     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-07-20     Completed Date:  1999-07-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  105-8     Citation Subset:  AIM; IM    
Department of Nephrology and Hypertension, Cleveland Clinic Foundation, Ohio 44195, USA.
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MeSH Terms
Adenoma / blood,  drug therapy*,  secretion*
Adrenal Gland Neoplasms / blood,  drug therapy*,  secretion*
Aldosterone / secretion*
Aldosterone Antagonists / therapeutic use
Antihypertensive Agents / therapeutic use
Blood Pressure
Diuretics / therapeutic use
Hyperaldosteronism / drug therapy,  etiology
Hypertension / drug therapy,  etiology
Middle Aged
Potassium / blood
Retrospective Studies
Spironolactone / therapeutic use
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Antihypertensive Agents; 0/Diuretics; 52-01-7/Spironolactone; 52-39-1/Aldosterone; 7440-09-7/Potassium
Comment In:
Ann Intern Med. 2000 Apr 4;132(7):594   [PMID:  10744604 ]
Ann Intern Med. 2000 Apr 4;132(7):593-4; author reply 594   [PMID:  10744603 ]

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