Document Detail


Medical management of acid-peptic disorders of the stomach.
MedLine Citation:
PMID:  16139027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the past 30 years, medicine has witnessed an unprecedented evolution in acid-peptic disorder management, fueled by major advances in our understanding of the physiology of acid secretion and the gastric mucosal barrier. The other pivotal development in understanding these disorders has been the recognition of Helicobacter pylori's role in the pathophysiology of peptic ulcer disease,chronic gastritis, and even gastric malignancy. This evolution continues as H pylori wanes in significance, and medicine is challenged by treating iatrogenic conditions brought on by ulcerogenic anti-inflammatory drugs. Following a description of the relevant physiology and biochemistry of gastric acid secretion and the gastric mucosal barrier, this article describes the current medicinal arsenal available to treat acid-peptic disorders of the stomach.
Authors:
Sheila Eswaran; Michael A Roy
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Surgical clinics of North America     Volume:  85     ISSN:  0039-6109     ISO Abbreviation:  Surg. Clin. North Am.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0074243     Medline TA:  Surg Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  895-906, v     Citation Subset:  AIM; IM    
Affiliation:
Portland Gastroenterology Associates, 1200 Congress Street, Suite 300 Portland, ME 04102-2129, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Ulcer Agents / pharmacology*
Gastric Acid / physiology*,  secretion
Gastric Mucosa / drug effects,  physiology,  physiopathology*
Humans
Peptic Ulcer / physiopathology*
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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