Document Detail

Medical conditions associated with a positive anti-double-stranded deoxyribonucleic acid.
MedLine Citation:
PMID:  20635012     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To explore the associated diseases with positive anti-double stranded (ds) DNA other than systemic lupus erythematosus (SLE), and to determine an association if any, between its level in non-SLE causes.
METHODS: This is a retrospective review of all patients with positive anti-dsDNA assay (more than 200 IU/ml) tested for any underlying etiology from January to December 2007 at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
RESULTS: Two hundred and twelve patients with anti-dsDNA antibody testing were evaluated. Of these, 124 patients had SLE (58.5%), while 88 patients (41.5%) had other diseases. Representing non-SLE diseases were: rheumatological disorders in 29 patients (33%), infections in 11 (12%), and malignancy in 6 patients (7%). Strong positive results (>800 IU/ml) were found in only 8 patients (4%) with diagnoses of antiphospholipid antibody syndrome, tuberculosis, osteomylitis, thymoma, lymphoma, sarcoidosis, and 2 autoimmune hepatitis patients. There was a statistically significant association between highly positive anti-dsDNA testing and rheumatological disorders.
CONCLUSION: Although positive anti-dsDNA test is common in SLE patients, other diseases should be considered when the anti-dsDNA level is equivocal, and the clinical criteria are not in favor of SLE.
Suzan M Attar; Emad A Koshak
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  31     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-11-01     Revised Date:  2011-03-09    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  781-7     Citation Subset:  IM    
Department of Internal Medicine, King Abdul-Aziz University Hospital, PO Box 80215, Jeddah 21589, Kingdom of Saudi Arabia.
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MeSH Terms
Antibodies, Antinuclear / blood*
Communicable Diseases / immunology*
DNA / immunology*
Enzyme-Linked Immunosorbent Assay
Lupus Erythematosus, Systemic / immunology*
Neoplasms / immunology*
Rheumatic Diseases / immunology*
Reg. No./Substance:
0/Antibodies, Antinuclear; 9007-49-2/DNA
Comment In:
Saudi Med J. 2011 Feb;32(2):204; author reply 204   [PMID:  21301775 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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