| Medical conditions associated with a positive anti-double-stranded deoxyribonucleic acid. | |
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MedLine Citation:
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PMID: 20635012 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To explore the associated diseases with positive anti-double stranded (ds) DNA other than systemic lupus erythematosus (SLE), and to determine an association if any, between its level in non-SLE causes. METHODS: This is a retrospective review of all patients with positive anti-dsDNA assay (more than 200 IU/ml) tested for any underlying etiology from January to December 2007 at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia. RESULTS: Two hundred and twelve patients with anti-dsDNA antibody testing were evaluated. Of these, 124 patients had SLE (58.5%), while 88 patients (41.5%) had other diseases. Representing non-SLE diseases were: rheumatological disorders in 29 patients (33%), infections in 11 (12%), and malignancy in 6 patients (7%). Strong positive results (>800 IU/ml) were found in only 8 patients (4%) with diagnoses of antiphospholipid antibody syndrome, tuberculosis, osteomylitis, thymoma, lymphoma, sarcoidosis, and 2 autoimmune hepatitis patients. There was a statistically significant association between highly positive anti-dsDNA testing and rheumatological disorders. CONCLUSION: Although positive anti-dsDNA test is common in SLE patients, other diseases should be considered when the anti-dsDNA level is equivocal, and the clinical criteria are not in favor of SLE. |
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Authors:
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Suzan M Attar; Emad A Koshak |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Saudi medical journal Volume: 31 ISSN: 0379-5284 ISO Abbreviation: Saudi Med J Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-16 Completed Date: 2010-11-01 Revised Date: 2011-03-09 |
Medline Journal Info:
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Nlm Unique ID: 7909441 Medline TA: Saudi Med J Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 781-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, King Abdul-Aziz University Hospital, PO Box 80215, Jeddah 21589, Kingdom of Saudi Arabia. suzan_attar@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Antinuclear
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blood* Communicable Diseases / immunology* DNA / immunology* Enzyme-Linked Immunosorbent Assay Humans Lupus Erythematosus, Systemic / immunology* Neoplasms / immunology* Rheumatic Diseases / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 9007-49-2/DNA |
| Comments/Corrections | |
Comment In:
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Saudi Med J. 2011 Feb;32(2):204; author reply 204
[PMID:
21301775
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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