Document Detail

Medical causes and consequences of hyperprolactinaemia. A context for psychiatrists.
MedLine Citation:
PMID:  18477618     Owner:  NLM     Status:  MEDLINE    
Hyperprolactinaemia is the commonest endocrine disorder of the hypothalamic-pituitary axis and can lead to both short-term sexual dysfunction and galactorrhoea, and long-term loss of bone mineral density. Prolactin is secreted from the anterior pituitary gland under the influence of dopamine, which exerts a tonic inhibitory effect on prolactin secretion. Physiological regulators of prolactin secretion include many different types of 'stress' and sleep. Disruption of the normal control of prolactin secretion results in hyperprolactinaemia from pathological and pharmacological causes. The administration of antipsychotic medication is responsible for the high prevalence of hyperprolactinaemia in people with severe mental illness. Physiological hyperprolactinaemia, such as pregnancy and lactation, should be distinguished from pathological causes to prevent unnecessary investigation and treatment. The causes, consequences and management of hyperprolactinaemia are discussed in this article.
Richard I G Holt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of psychopharmacology (Oxford, England)     Volume:  22     ISSN:  0269-8811     ISO Abbreviation:  J. Psychopharmacol. (Oxford)     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-05-14     Completed Date:  2008-09-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907828     Medline TA:  J Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  28-37     Citation Subset:  IM    
Endocrinology and Metabolism Subdivision, Developmental Origins of Health and Disease, School of Medicine, University of Southampton, Southampton, UK.
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MeSH Terms
Antipsychotic Agents / adverse effects*
Hyperprolactinemia / chemically induced,  complications,  diagnosis,  etiology*,  metabolism,  therapy
Mental Disorders / complications,  drug therapy*
Pituitary Gland / drug effects*,  secretion
Prolactin / secretion*
Risk Factors
Reg. No./Substance:
0/Antipsychotic Agents; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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