| Medical applications of Raman spectroscopy: from proof of principle to clinical implementation. | |
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MedLine Citation:
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PMID: 11842408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Raman spectroscopy has recently been applied ex vivo and in vivo to address various biomedical issues such as the early detection of cancers, monitoring of the effect of various agents on the skin, determination of atherosclerotic plaque composition, and rapid identification of pathogenic microorganisms. This leap in the number of applications and the number of groups active in this field has been facilitated by several technological advancements in lasers, CCD detectors, and fiber-optic probes. However, most of the studies are still at the proof of concept stage. We present a discussion on the status of the field today, as well as the problems and issues that still need to be resolved to bring this technology to hospital settings (i.e., the medical laboratory, surgical suites, or clinics). Taken from the viewpoint of clinicians and medical analysts, the potential of Raman spectroscopic techniques as new tools for biomedical applications is discussed and a path is proposed for the clinical implementation of these techniques. |
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Authors:
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L-P Choo-Smith; H G M Edwards; H P Endtz; J M Kros; F Heule; H Barr; J S Robinson; H A Bruining; G J Puppels |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biopolymers Volume: 67 ISSN: 0006-3525 ISO Abbreviation: Biopolymers Publication Date: 2002 |
Date Detail:
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Created Date: 2002-02-13 Completed Date: 2002-04-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372525 Medline TA: Biopolymers Country: United States |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Copyright Information:
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Copyright 2002 John Wiley & Sons, Inc. |
Affiliation:
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Laboratory for Intensive Care Research and Optical Spectroscopy, Erasmus University Rotterdam, Rotterdam, The Netherlands. lin-p'ing.choo-smith@nrc.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteriosclerosis
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diagnosis Bacteremia / diagnosis Clinical Trials as Topic Humans Precancerous Conditions / diagnosis Skin / chemistry Skin Diseases, Bacterial / diagnosis Skin Neoplasms / diagnosis Spectrum Analysis, Raman / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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