| Medical management of Lennox-Gastaut syndrome. | |
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MedLine Citation:
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PMID: 20158289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lennox-Gastaut syndrome occurs in 3% of children with epilepsy and is characterized by multiple seizure types, slow spike-and-wave discharges and a poor prognosis for seizure control and cognitive development. Although randomized controlled trials of adjunctive felbamate, lamotrigine, topiramate and rufinamide have demonstrated a > or =50% reduction in seizure frequency, very few children achieve complete seizure control and a Cochrane review of the treatment of Lennox-Gastaut syndrome concluded that the optimum treatment was uncertain and that no drug has been shown to be highly efficacious. Valproate, lamotrigine and topiramate were considered recently by expert panels in the US and Europe to be the first-line drugs. The ketogenic diet may be more effective than antiepileptic drugs and should be considered early in treatment. An improvement in the management of Lennox-Gastaut syndrome requires a better understanding of the pathophysiology of this disorder and the development of animal models in which to test new compounds. |
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Authors:
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Aspasia Michoulas; Kevin Farrell |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: CNS drugs Volume: 24 ISSN: 1172-7047 ISO Abbreviation: CNS Drugs Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-06-25 Revised Date: 2011-12-06 |
Medline Journal Info:
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Nlm Unique ID: 9431220 Medline TA: CNS Drugs Country: New Zealand |
Other Details:
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Languages: eng Pagination: 363-74 Citation Subset: IM |
Affiliation:
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Division of Neurology, Department of Pediatrics, University of British Columbia and British Columbia's Children's Hospital, Vancouver, British Columbia, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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administration & dosage,
adverse effects,
therapeutic use* Child Cognition / drug effects Electroencephalography Epilepsy, Generalized / drug therapy*, epidemiology, psychology Humans Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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