| Medical care of girls with Turner Syndrome: where are we lacking? | |
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MedLine Citation:
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PMID: 21454226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To characterize the medical care of a large cohort of girls with Turner syndrome with a focus on changes in management since establishment of international consensus guidelines in 2007. METHODS: We reviewed medical records of patients followed up for Turner syndrome between 2000 and 2010. RESULTS: A total of 128 girls aged 13.2 ± 0.5 years were identified. Average age at diagnosis was 4.1 ± 5.1 years. Overall, medical assessments performed included a hearing test in 56%, thyroid screening in 95%, renal ultrasonography in 100%, and echocardiography in 100%. Before 2007, none of the patients had screening performed for celiac disease, dyslipidemia, or liver dysfunction, and none had routine electrocardiography or cardiac magnetic resonance imaging. Since 2007, 63% were screened for celiac disease, 54% for liver abnormalities, and 38% for dyslipidemia. Electrocardiography was performed in 23%, while cardiac magnetic resonance imaging was performed in 39%. Although conjugated equine oral estrogen was the main mode of estrogen replacement, a significant increase was noted in the use of transdermal estrogen during the past 2 years compared with that observed in the earlier interval (78% vs 10%, respectively). CONCLUSIONS: Although changes in medical practice have occurred since establishment of the international Turner syndrome guidelines, screening for associated comorbidities was deficient in greater than 50% of the patients in our study. This is the first study evaluating medical care in a large cohort of pediatric patients with Turner syndrome, and our findings emphasize the need for continual education of all physicians involved in the care of this population. |
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Authors:
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Zeina M Nabhan; Erica A Eugster |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: 17 ISSN: 1934-2403 ISO Abbreviation: Endocr Pract Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-10-11 Completed Date: 2012-05-11 Revised Date: 2012-05-23 |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: United States |
Other Details:
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Languages: eng Pagination: 747-52 Citation Subset: IM |
Affiliation:
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Department of Pediatric Endocrinology and Diabetology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, USA. znabhan@iupui.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Echocardiography Estrogen Replacement Therapy Estrogens, Conjugated (USP) / therapeutic use Female Humans Magnetic Resonance Imaging Turner Syndrome / diagnosis*, drug therapy, pathology |
| Chemical | |
Reg. No./Substance:
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0/Estrogens, Conjugated (USP) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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