| Mediators of hypersensitivity and "fog"-induced asthma. | |
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MedLine Citation:
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PMID: 2579599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven asthmatic and five normal subjects inhaled increasing amounts of nebulized water ("fog"). Neutrophil chemotactic activity (NCA), histamine and FEV1 measurements were undertaken before and at time intervals after challenge. In asthmatics, the mean maximal reduction in FEV1 (+/- 1 SD) was 46.6% +/- 11.5; whereas, in normal subjects, the reductions were less than 20% of pre-challenge values after the inhalation of 33 ml of water. There were no significant differences in the pre-challenge values for NCA between the asthmatics and the normal controls. When the highest values for NCA during the 30 min after challenge in the asthmatics were compared with controls there was a significant increase (P less than 0.02). The percentage change in NCA was also significantly greater in the asthmatics compared with the controls at 10 min after challenge (P less than 0.05). Fog-induced NCA was shown to be associated with proteins with approximate molecular weight of 600,000 daltons (as assessed by gel filtration chromatography on Sephacryl-S400). There was an increase in plasma histamine in the asthmatics after challenge but this was not significantly greater than the controls. These findings support the view that mediators might be involved in fog-induced asthma, possibly as a result of mast cell degranulation by "osmotic shock". |
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Authors:
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R J Shaw; S D Anderson; S R Durham; K M Taylor; R E Schoeffel; W Green; P Torzillo; A B Kay |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Allergy Volume: 40 ISSN: 0105-4538 ISO Abbreviation: Allergy Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-03-27 Completed Date: 1985-03-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7804028 Medline TA: Allergy Country: DENMARK |
Other Details:
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Languages: eng Pagination: 48-57 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aerosols Amine Oxidase (Copper-Containing) / blood Asthma / etiology, immunology* Bronchial Provocation Tests Chemotaxis, Leukocyte Chromatography, Gel Female Histamine Release Humans Male Middle Aged Neutrophils / physiopathology Water / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 7732-18-5/Water; EC 1.4.3.6/Amine Oxidase (Copper-Containing) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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