Document Detail

Mediators and cytokines in allergic and viral-triggered rhinitis.
MedLine Citation:
PMID:  17883911     Owner:  NLM     Status:  MEDLINE    
Intermittent allergic rhinitis and common cold constitute frequent conditions and show similar clinical symptoms. The purpose of this study was to investigate the pattern of cytokines in the nasal fluid of patients with acute symptoms caused by allergic and viral rhinitis. Nasal secretions were analyzed by immunosorbent assay techniques using a cytokine panel assay and routine ELISA. Allergic patients had significantly higher levels of eosinophil cationic protein (ECP), interleukin (IL)-5, and tryptase. Significantly elevated concentrations of proinflammatory cytokines (IL-1b, IL-6, IL-7, IL-17, interferon [IFN] gamma, and tumor necrosis factor [TNF]-alpha) as well as chemokines for cellular infiltration (IL-8, monocyte chemoattractant protein 1, and macrophage inflammatory protein 1beta), factors for cellular proliferation (granulocyte colony-stimulating factor [G-CSF] and granulocyte macrophage colony-stimulating factor [GM-CSF]), and elastase were found in viral rhinitis. IL-10 was only detectable in viral rhinitis. IL-4 was significantly higher in patients with viral rhinitis than allergic rhinitis, and IL-5 was significantly elevated in viral rhinitis compared with controls. In viral-triggered rhinitis, we detected a predominantly Th1-type cytokine pattern with potent proinflammatory mediators. Factors reflecting a neutrophil and eosinophil immune response, due to IL-5, IL-8, GM-CSF, ECP, and elastase were shown. Nasal secretions of patients with allergic rhinitis showed highest concentrations of tryptase, IL-5, and ECP, reflecting a mast cell and eosinophil immune response. Nasal secretion levels of IL-4 did not show highest levels in allergic rhinitis but did in viral rhinitis. IL-4 also may play a role in limiting inflammatory processes by inhibiting the production of inflammatory cytokines.
Christine Klemens; Gerd Rasp; Fenna Jund; Eva Hilgert; Cordula Devens; Elisabeth Pfrogner; Matthias F Kramer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy and asthma proceedings : the official journal of regional and state allergy societies     Volume:  28     ISSN:  1088-5412     ISO Abbreviation:  Allergy Asthma Proc     Publication Date:    2007 Jul-Aug
Date Detail:
Created Date:  2007-09-24     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9603640     Medline TA:  Allergy Asthma Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  434-41     Citation Subset:  IM    
Department of Otorhinolaryngology-Head and Neck Surgery, Ludwig-Maximilians-University Munich, Germany.
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MeSH Terms
Case-Control Studies
Cytokines / analysis*
Eosinophils / immunology
Immunologic Factors / analysis*
Interleukin-4 / physiology
Mast Cells / immunology
Middle Aged
Neutrophils / immunology
Rhinitis / immunology,  virology*
Rhinitis, Allergic, Perennial / immunology*
Reg. No./Substance:
0/Cytokines; 0/Immunologic Factors; 207137-56-2/Interleukin-4

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