| Mediators of Systemic Inflammatory Response Syndrome and the Role of Recombinant Activated Protein C in Sepsis Syndrome. | |
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MedLine Citation:
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PMID: 22054759 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The systemic inflammatory response syndrome, the host's response to infection involves a series of cascading events that mobilize a series of mediators involving the immune system, complement, and the coagulation cascade. Although the initial focus of mediators is to limit infection, this cascade may run amok and cause the development of hypotension, vascular instability, and disseminated intravascular coagulation, leading to morbidity and mortality in the host. Several therapeutic trials have focused on the modulation of these mediators, but use of recombinant human activated protein C in patients with severe sepsis is the only one that has shown a benefit in clinical trials. |
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Authors:
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Vivek Kak |
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Publication Detail:
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Type: Journal Article Date: 2011-09-09 |
Journal Detail:
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Title: Infectious disease clinics of North America Volume: 25 ISSN: 1557-9824 ISO Abbreviation: Infect. Dis. Clin. North Am. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804508 Medline TA: Infect Dis Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 835-50 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Infectious Diseases, Allegiance Health, 1100 East Michigan Avenue, #305, Jackson, MI 49201, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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