Document Detail

Mediator--a universal complex in transcriptional regulation.
MedLine Citation:
PMID:  11454195     Owner:  NLM     Status:  MEDLINE    
The Mediator complex is essential for basal and regulated expression of nearly all RNA polymerase II-dependent genes in the Saccharomyces cerevisiae genome. Mediator acts as a bridge, conveying regulatory information from enhancers and other control elements to the promoter. It is now clear that Mediator-like complexes also exist in higher eukaryotic cells and that they have an important role in metazoan transcriptional regulation. However, the exact mechanism of Mediator-dependent transcriptional regulation remains unclear. We review here some recent advances in our understanding of Mediator structure and function. We also discuss a model to account for the functional and evolutionary relationship between yeast and metazoan Mediators. As an appendix to this review, we have created a database, MEDB, in which we have compiled information about all the S. cerevisiae Mediator subunits and their homologues in other eukaryotic cells (
C M Gustafsson; T Samuelsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular microbiology     Volume:  41     ISSN:  0950-382X     ISO Abbreviation:  Mol. Microbiol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-16     Completed Date:  2001-12-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8712028     Medline TA:  Mol Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Department of Medical Nutrition, Karolinska Institute, Novum, S-141 86 Huddinge, Sweden.
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MeSH Terms
Fungal Proteins* / genetics,  metabolism
Gene Expression Regulation, Fungal*
RNA Polymerase II / metabolism
Saccharomyces cerevisiae / genetics,  metabolism*
Transcription Factors* / genetics,  metabolism
Transcriptional Activation*
Reg. No./Substance:
0/Fungal Proteins; 0/Transcription Factors; EC 2.7.7.-/RNA Polymerase II

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