Document Detail


Mediator--a universal complex in transcriptional regulation.
MedLine Citation:
PMID:  11454195     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Mediator complex is essential for basal and regulated expression of nearly all RNA polymerase II-dependent genes in the Saccharomyces cerevisiae genome. Mediator acts as a bridge, conveying regulatory information from enhancers and other control elements to the promoter. It is now clear that Mediator-like complexes also exist in higher eukaryotic cells and that they have an important role in metazoan transcriptional regulation. However, the exact mechanism of Mediator-dependent transcriptional regulation remains unclear. We review here some recent advances in our understanding of Mediator structure and function. We also discuss a model to account for the functional and evolutionary relationship between yeast and metazoan Mediators. As an appendix to this review, we have created a database, MEDB, in which we have compiled information about all the S. cerevisiae Mediator subunits and their homologues in other eukaryotic cells (http://bio.lundberg.gu.se/medb/).
Authors:
C M Gustafsson; T Samuelsson
Related Documents :
24658785 - The iclr-family regulator bapr controls biofilm formation in b. cenocepacia h111.
23399735 - Microrna-224 negatively regulates p21 expression during late neoplastic progression in ...
23680185 - Activation of the nuclear receptor fxr enhances hepatocyte chemoprotection and liver tu...
23370975 - Induction of klf4 contributes to the neurotoxicity of mpp + in m17 cells: a new implica...
10683435 - Inositol polyphosphate multikinase (argriii) determines nuclear mrna export in saccharo...
19671685 - Nf-kappab activation, dependent on acetylation/deacetylation, contributes to hif-1 acti...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular microbiology     Volume:  41     ISSN:  0950-382X     ISO Abbreviation:  Mol. Microbiol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-16     Completed Date:  2001-12-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8712028     Medline TA:  Mol Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Department of Medical Nutrition, Karolinska Institute, Novum, S-141 86 Huddinge, Sweden. claes.gustafsson@mednut.ki.se
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Fungal Proteins* / genetics,  metabolism
Gene Expression Regulation, Fungal*
RNA Polymerase II / metabolism
Saccharomyces cerevisiae / genetics,  metabolism*
Transcription Factors* / genetics,  metabolism
Transcriptional Activation*
Chemical
Reg. No./Substance:
0/Fungal Proteins; 0/Transcription Factors; EC 2.7.7.-/RNA Polymerase II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute liver failure as the initial manifestation of acute leukaemia.
Next Document:  Feedback controls restrain the initiation of Escherichia coli chromosomal replication.