Document Detail

Mediation of glucose-induced anorexia by central nervous system interleukin 1 signaling.
MedLine Citation:
PMID:  24013028     Owner:  NLM     Status:  Publisher    
Hypothalamic glucose sensing plays a critical role in the regulation of food intake and metabolism. Glucose injection, either centrally or peripherally suppresses food intake. However, the mechanism of glucose-induced feeding suppression is not fully understood. It has been demonstrated that hypothalamic interleukin 1 beta (IL-1β) mRNA levels are altered by metabolic states and IL-1 signaling participates in the regulation of food intake. Therefore, we hypothesized that hypothalamic IL-1 gene expression is regulated by glucose and glucose-induced feeding suppression is mediated via hypothalamic IL-1 signaling. To address this hypothesis, we examined the effect of glucose on IL-1α and IL-1β mRNA expression in the hypothalamus. We also examined the effect of intraperitoneal injection of glucose on food intake in wild-type and type I IL-1 receptor (IL-1RI)-deficient mice. Levels of IL-1α and IL-1β mRNA in the hypothalamus were increased in response to feeding and intraperitoneal injection of glucose, and were positively correlated with blood glucose levels in mice. Exposure of hypothalamic explants to high glucose (10mM) media increased IL-1α and IL-1β mRNA levels compared to low glucose (1mM) media. Intraperitoneal glucose administration reduced food intake in wild-type mice, while the feeding-suppressing effect of glucose was attenuated in IL-1RI-deficient mice. These findings support the role for hypothalamic IL-1 signaling in the mediation of the anorectic effect of glucose.
Tooru M Mizuno; Pei San Lew; Alexandra Spirkina; Yang Xu
Related Documents :
24712378 - Evaluation of yellow pea fibre supplementation on weight loss and the gut microbiota: a...
3556678 - Arsenic, cadmium, lead and mercury in meat, livers and kidneys of cattle slaughtered in...
16192068 - Predicted intake of trace elements and minerals via household drinking water by 6-year-...
23434938 - Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like p...
16015658 - Comparisons of food availability and group density of japanese macaques in primary, nat...
12027278 - An accelerated nutrition transition in iran.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-4
Journal Detail:
Title:  Behavioural brain research     Volume:  -     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
Department of Physiology and Pathophysiology, Division of Endocrinology & Metabolic Disease, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Serotonin directly stimulates cortisol secretion from the interrenals in goldfish.
Next Document:  Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-m...