| Mediastinal nodal staging of nonsmall cell lung cancer using integrated 18F-FDG PET/CT in a tuberculosis-endemic country: diagnostic efficacy in 674 patients. | |
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MedLine Citation:
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PMID: 17311309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Integrated (18)fluorine fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) has shown somewhat variable sensitivity and specificity for mediastinal nodal staging in granulomatous disease endemic areas. The purpose of the study was to prospectively evaluate the efficacy of PET/CT for mediastinal nodal staging in nonsmall cell lung cancer (NSCLC) patients in a tuberculosis-endemic country. METHODS: Prospective assessment of the diagnostic efficacy of integrated PET/CT for detecting mediastinal nodal metastasis was performed in 674 patients (M:F ratio = 502:172; mean age, 61 years) with NSCLC. Patients underwent an integrated PET/CT examination and subsequent surgical nodal staging (by mediastinoscopy only in 121 patients and by thoracotomy in 553). Nodes showing greater (18)F-FDG uptake than mediastinum at PET without benign calcification or high attenuation >70 household unit (HU) at unenhanced CT were regarded as being positive for malignancy. The histologic nodal assessment results were used as reference standards. RESULTS: Of 2477 mediastinal nodal stations evaluated in 674 patients, 275 (11%) stations in 180 (27%) patients proved to be malignant. On a per-person basis, the overall sensitivity, specificity, and accuracy of PET/CT for mediastinal nodal staging were 61% (110 of 180), 96% (473 of 494), and 86% (583 of 674), respectively. On a per-nodal station basis, they were 46% (126 of 275), 98% (2154 of 2202), and 92% (2280 of 2477). CONCLUSIONS: Integrated PET/CT provides high specificity and reasonably high accuracy, but somewhat low sensitivity for mediastinal nodal staging of NSCLCs. The high specificity is achieved at the expense of sensitivity by interpreting calcified nodes or nodes with high attenuation at CT, even with high FDG uptake at PET, as benign in a tuberculosis-endemic region. |
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Authors:
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Yoon Kyung Kim; Kyung Soo Lee; Byung-Tae Kim; Joon Young Choi; Hojoong Kim; O Jung Kwon; Young Mog Shim; Chin A Yi; Ha Young Kim; Myung Jin Chung |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Cancer Volume: 109 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-15 Completed Date: 2007-05-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1068-77 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung / pathology, radionuclide imaging* Female Fluorodeoxyglucose F18 / diagnostic use* Humans Lung Neoplasms / pathology, radionuclide imaging* Lymph Nodes / pathology Lymphatic Metastasis Male Mediastinum / pathology Middle Aged Neoplasm Staging Positron-Emission Tomography / methods* Sensitivity and Specificity Tuberculosis, Pulmonary / epidemiology |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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