Document Detail


Mediastinal extravasation of doxorubicin.
MedLine Citation:
PMID:  18258513     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 48-year-old woman with a diagnosis of breast carcinoma was treated with adjuvant chemotherapy through a central venous catheter with subcutaneous reservoir (Port-A-Cath). While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum. The patient recovered without sequelae with conservative therapy. Cytostatic extravasation via central catheter is an uncommon complication in clinical practice. In this paper we present the first doxorubicin extravasation through a central catheter in adults and review the only ten cases found in the literature.
Authors:
Teresa Quintanar Verdúguez; Adolfo Blanco Jarava; María Blanca Martínez-Barbeito; Cristina Pangua Méndez; Luis López Gómez; Jesús Andrade Santiago; Ignacio Chacón López-Muñiz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico     Volume:  10     ISSN:  1699-048X     ISO Abbreviation:  -     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-08     Completed Date:  2008-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247119     Medline TA:  Clin Transl Oncol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  128-30     Citation Subset:  IM    
Affiliation:
Servicio de Oncología Médica, Hospital Virgen de la Salud, Toledo, Spain. teresaqv@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / administration & dosage*
Breast Neoplasms / drug therapy*
Catheterization, Central Venous / adverse effects*
Catheters, Indwelling / adverse effects
Doxorubicin / administration & dosage*
Extravasation of Diagnostic and Therapeutic Materials / complications*
Female
Humans
Infusions, Intravenous
Mediastinum / pathology*
Middle Aged
Pleural Effusion / etiology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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