| Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women. | |
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MedLine Citation:
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PMID: 22365285 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To develop Thai-specific medians of serum pregnancy-associated plasma protein A (PAPP-A) and free β-human chorionic gonadotropin (hCG) levels during the first trimester of pregnancy and to compare these values to a Caucasian-specific model for the detection of fetal Down syndrome. METHODS: Serum concentrations of PAPP-A and free β-hCG were measured during the first trimester in a group of 2339 Thai women undergoing normal singleton pregnancies. RESULTS: Thai reference ranges of PAPP-A and free β-hCG were established by gestational age (70-98days). The equation of best fit for PAPP-A was: predicted median PAPP-A level=28.767 - 0.781×(gestational age in days)+0.006×(gestational age in days)(2); r=0.986. The equation of best fit for free β-hCG was: predicted median free β-hCG level=465.332×10((-0.024×gestational age in days)); r=0.881. Weight-corrected models were also derived for each biomarker. The Thai-specific reference ranges gave higher positive screening rates than the Caucasian-specific model, even after weight correction (5.1% versus 4.0%). The Thai-specific models were validated in an independent group of 302 pregnant women. CONCLUSION: Ethnic group-specific medians for PAPP-A and free β-hCG should be incorporated during first-trimester screening for fetal Down syndrome. |
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Authors:
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Suchaya Luewan; Supatra Sirichotiyakul; Yuri Yanase; Kuntharee Traisrisilp; Theera Tongsong |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-24 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: - ISSN: 1879-3479 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 International Federation of Gynecology and Obstetrics. All rights reserved. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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