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Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women.
MedLine Citation:
PMID:  22365285     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To develop Thai-specific medians of serum pregnancy-associated plasma protein A (PAPP-A) and free β-human chorionic gonadotropin (hCG) levels during the first trimester of pregnancy and to compare these values to a Caucasian-specific model for the detection of fetal Down syndrome. METHODS: Serum concentrations of PAPP-A and free β-hCG were measured during the first trimester in a group of 2339 Thai women undergoing normal singleton pregnancies. RESULTS: Thai reference ranges of PAPP-A and free β-hCG were established by gestational age (70-98days). The equation of best fit for PAPP-A was: predicted median PAPP-A level=28.767 - 0.781×(gestational age in days)+0.006×(gestational age in days)(2); r=0.986. The equation of best fit for free β-hCG was: predicted median free β-hCG level=465.332×10((-0.024×gestational age in days)); r=0.881. Weight-corrected models were also derived for each biomarker. The Thai-specific reference ranges gave higher positive screening rates than the Caucasian-specific model, even after weight correction (5.1% versus 4.0%). The Thai-specific models were validated in an independent group of 302 pregnant women. CONCLUSION: Ethnic group-specific medians for PAPP-A and free β-hCG should be incorporated during first-trimester screening for fetal Down syndrome.
Authors:
Suchaya Luewan; Supatra Sirichotiyakul; Yuri Yanase; Kuntharee Traisrisilp; Theera Tongsong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-24
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  -     ISSN:  1879-3479     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 International Federation of Gynecology and Obstetrics. All rights reserved.
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