Document Detail

Medial vs lateral wall pyriform sinus carcinoma: implications for management of regional lymphatics.
MedLine Citation:
PMID:  7960736     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Our purpose in performing this review is to analyze the relationship between the anatomic site of hypopharyngeal lesions and the pattern of recurrent disease, particularly cervical recurrence. This clinical information can subsequently be used to influence treatment options. METHODS: The records of 169 patients with carcinoma of the hypopharynx treated between 1975 and 1986 were reviewed retrospectively. Patients were classified as having medial wall pyriform sinus disease (MP) lesions, lateral wall pyriform sinus (LP) lesions, posterior wall (PW), or postcricoid (PC) lesions. All patients were followed a minimum of 36 months. Patients with evidence of recurrent carcinoma were characterized according to the site of recurrence. RESULTS: Recurrent carcinoma in the hypopharynx was noted in seven (4%) of 169 patients. Cervical metastases was the sole site of failure in 27 (16%) of 69 patients, whereas distant metastases developed in 25 (15%) of 169 patients. Failure in the contralateral unoperated neck occurred in 14% (10/71) of patients with MP lesions and, in contrast, 5% (4/76) LP patients. This difference was statistically significant (p = 0.04). Radiotherapy was not effective in preventing cervical recurrence in 20 (74%) of 27 overall neck failures and 11 (79%) of 14 contralateral NO neck failures. CONCLUSION: These data suggest that patients with carcinoma involving the MP are at greater risk for contralateral cervical metastases. We recommend bilateral neck dissection be offered to patients with MP lesions.
J T Johnson; G W Bacon; E N Myers; R L Wagner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Head & neck     Volume:  16     ISSN:  1043-3074     ISO Abbreviation:  Head Neck     Publication Date:    1994 Sep-Oct
Date Detail:
Created Date:  1994-12-21     Completed Date:  1994-12-21     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-5     Citation Subset:  IM    
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pennsylvania.
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MeSH Terms
Aged, 80 and over
Carcinoma / pathology*,  radiotherapy,  surgery
Cause of Death
Combined Modality Therapy
Follow-Up Studies
Head and Neck Neoplasms / pathology,  secondary*
Hypopharyngeal Neoplasms / pathology*,  radiotherapy,  surgery
Lymph Node Excision
Lymphatic Metastasis / pathology*
Middle Aged
Neoplasm Recurrence, Local / pathology*
Neoplasm Staging
Pharyngeal Neoplasms / pathology*,  radiotherapy,  surgery
Retrospective Studies
Survival Rate
Treatment Failure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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