Document Detail

Medial smooth-muscle cell lesions and dissection of the aorta and muscular arteries.
MedLine Citation:
PMID:  2294868     Owner:  NLM     Status:  MEDLINE    
We report a case of aortic, coronary, and renal artery dissections associated with pregnancy. The histologic changes related to the hemorrhages included smooth-muscle cell (SMC) proliferation with fibrosis, elastin fragmentation and collagen degeneration, and SMC vacuolar degeneration and coagulation necrosis. These lesions seemed to be prototypes for dissection, since they were associated with aortic and muscular artery dissections in three additional cases unrelated to pregnancy. In each case, dissections seemed to result from SMC activity that also involved the systemic vasculature, veins, and visceral smooth muscle in histologic patterns that could be explained as a product of SMC metabolism. We propose that the histologic changes associated with dissections are best explained as a product of the metabolism of SMCs that function as multifunctional mesenchyma in a manner controlled by variable penetrance of a gene that controls their metabolism.
J D Hartman; A S Eftychiadis
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  114     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-01     Completed Date:  1990-02-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-61     Citation Subset:  AIM; IM    
Department of Laboratories, Albert Einstein Medical Center, Philadelphia, PA 19141.
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MeSH Terms
Aneurysm, Dissecting / metabolism,  pathology*
Aorta / pathology
Aorta, Thoracic / pathology
Aortic Aneurysm / metabolism,  pathology*
Carotid Artery Diseases / pathology
Coronary Disease / pathology
Hemorrhage / pathology
Middle Aged
Muscle, Smooth, Vascular / metabolism,  pathology*
Renal Artery / pathology
Subarachnoid Hemorrhage / pathology

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