Document Detail


Medial septal nucleus theta frequency deep brain stimulation improves spatial working memory following traumatic brain injury.
MedLine Citation:
PMID:  23016534     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Over five million survivors of traumatic brain injury (TBI) live with persistent cognitive deficits, some of which likely derive from hippocampal dysfunction. Oscillatory activity in the hippocampus is critical for normal learning and memory functions, and can be modulated using deep brain stimulation techniques. In this pre-clinical study, we demonstrate that lateral fluid percussion TBI results in the attenuation of hippocampal theta oscillations in the first 6 days after injury that correlate with deficits in the Barnes maze spatial working memory task. Theta-band stimulation of the medial septal nucleus (MSN) results in a transient increase in hippocampal theta activity, and when delivered one-minute prior to training in the Barnes maze, it significantly improves spatial working memory. These results suggest that MSN theta stimulation may be an effective neuromodulatory technique for treatment of persistent learning and memory deficits after TBI.
Authors:
Darrin Jason Lee; Gene Gabriel Gurkoff; Ali Izadi; Robert F Berman; Arne D Ekstrom; J Paul Muizelaar; Bruce G Lyeth; Kiarash Shahlaie
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  Journal of neurotrauma     Volume:  -     ISSN:  1557-9042     ISO Abbreviation:  J. Neurotrauma     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of California, Davis, Neurological Surgery, 4860 Y Street, Suite 3740, Sacramento, California, United States, 95817; darrin.lee@ucdmc.ucdavis.edu.
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