Document Detail

Medial knee joint loading increases in those who respond to hyaluronan injection for medial knee osteoarthritis.
MedLine Citation:
PMID:  19408285     Owner:  NLM     Status:  MEDLINE    
Knee osteoarthritis (OA) is a cause of decline in function and the medial compartment is often affected. Intraarticular injection of hyaluronic acid (HA) is indicated as a symptom modifying treatment with at least 6 months passing between consecutive injection series. The effects of HA injection on gait variables have not been extensively examined. Therefore, our objective was to investigate the effects of HA injection on gait in people with medial knee OA. Twenty-seven subjects were included; each was tested prior to treatment (baseline), no later than 3 weeks following the last injection (post-HA), and again 5 months after treatment ended (follow-up). Responder criteria were defined to identify responders and non-responders. Subjects underwent 3D gait analysis, muscle activity was sampled, and co-contraction indices were calculated. Responders experienced increased peak knee adduction moments post-HA, whereas non-responders did not. Improved self-report scores were associated with increased knee adduction moments and increased medial co-contraction. Pain relief may result in higher loading onto the already vulnerable medial compartment due to changes in lower limb mechanics and muscle activation patterns. Eventually this may result in a more rapid progression of joint deterioration.
Kristin Briem; Michael J Axe; Lynn Snyder-Mackler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  27     ISSN:  1554-527X     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-21     Completed Date:  2009-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1420-5     Citation Subset:  IM    
Copyright Information:
(c) 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Research Centre of Movement Science School of Health Sciences, University of Iceland, Reykjavik, Iceland.
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MeSH Terms
Gait / physiology
Hyaluronic Acid / administration & dosage,  therapeutic use*
Injections, Intra-Articular
Knee Joint / physiopathology
Middle Aged
Osteoarthritis, Knee / drug therapy*,  physiopathology*
Grant Support
Reg. No./Substance:
9004-61-9/Hyaluronic Acid

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