Document Detail

The Medi-RIVAGE study: reduction of cardiovascular disease risk factors after a 3-mo intervention with a Mediterranean-type diet or a low-fat diet.
MedLine Citation:
PMID:  16280426     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Epidemiologic studies link Mediterranean-type diets to a low incidence of cardiovascular disease; however, few dietary intervention studies have been undertaken, especially in primary prevention. OBJECTIVES: In the Mediterranean Diet, Cardiovascular Risks and Gene Polymorphisms (Medi-RIVAGE) study, the effects of a Mediterranean-type diet (Med group) or a low-fat diet (low-fat group) on risk factors were evaluated in 212 volunteers (men and women) with moderate risk factors for cardiovascular disease. DESIGN: After the 3-mo dietary intervention, changes in many risk factors were evaluated. Dietary questionnaires and plasma nutritional markers were used to test compliance. RESULTS: Although the dietary goals were only partially reached, changes in dietary habits were observed in both groups (n = 169): protein, carbohydrate, and fiber intakes increased and fat quality (decreased saturated fat and increased monounsaturated or polyunsaturated fat) improved. BMI, total and triacylglycerol-rich lipoprotein (TRL) cholesterol, triacylglycerols, TRL triacylglycerols, apolipoproteins A-I and B, insulinemia, glycemia, and the homeostasis model assessment score were significantly lower after 3 mo. The reductions in total cholesterol, triacylglycerols, and insulinemia remained significant after adjustment for BMI. There was a trend for a diet-by-time interaction for LDL cholesterol (P = 0.09). Our data predicted a 9% reduction in cardiovascular disease risk with the low-fat diet and a 15% reduction with this particular Mediterranean diet. CONCLUSION: After a 3-mo intervention, both diets significantly reduced cardiovascular disease risk factors to an overall comparable extent.
Stephanie Vincent-Baudry; Catherine Defoort; Mariette Gerber; Marie-Christine Bernard; Pierre Verger; Olfa Helal; Henri Portugal; Richard Planells; Pascal Grolier; Marie-Josephe Amiot-Carlin; Philippe Vague; Denis Lairon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  82     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-10     Completed Date:  2005-12-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  964-71     Citation Subset:  AIM; IM    
Human Nutrition and Lipids Joint Research Unit 476-INSERM, National Institute of Health and Medical Research/1260-National Institute of Agronomic Research, Faculty of Medicine Timone, Université de la Méditerranée, Marseille, France.
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MeSH Terms
Analysis of Variance
Biological Markers / blood
Body Mass Index
Cardiovascular Diseases / blood,  epidemiology,  prevention & control*
Cholesterol / blood*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Diet, Fat-Restricted*
Diet, Mediterranean*
Insulin / blood*
Lipid Metabolism / genetics,  physiology
Middle Aged
Patient Compliance
Polymorphism, Genetic
Primary Prevention / methods
Risk Factors
Triglycerides / blood*
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol
Comment In:
Am J Clin Nutr. 2006 Apr;83(4):921; author reply 921-2   [PMID:  16600949 ]

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