Document Detail

Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses.
MedLine Citation:
PMID:  9502724     Owner:  NLM     Status:  MEDLINE    
Mothers against dpp (Mad) mediates Decapentaplegic (DPP) signaling throughout Drosophila development. Here we demonstrate that Medea encodes a MAD-related protein that functions in DPP signaling. MEDEA is most similar to mammalian Smad4 and forms heteromeric complexes with MAD. Like dpp, Medea is essential for embryonic dorsal/ventral patterning. However, Mad is essential in the germline for oogenesis whereas Medea is dispensable. In the wing primordium, loss of Medea most severely affects regions receiving low DPP signal. MEDEA is localized in the cytoplasm, is not regulated by phosphorylation, and requires physical association with MAD for nuclear translocation. Furthermore, inactivating MEDEA mutations prevent nuclear translocation either by preventing interaction with MAD or by trapping MAD/MEDEA complexes in the cytosol. Thus MAD-mediated nuclear translocation is essential for MEDEA function. Together these data show that, while MAD is essential for mediating all DPP signals, heteromeric MAD/MEDEA complexes function to modify or enhance DPP responses. We propose that this provides a general model for Smad4/MEDEA function in signaling by the TGF-beta family.
R G Wisotzkey; A Mehra; D J Sutherland; L L Dobens; X Liu; C Dohrmann; L Attisano; L A Raftery
Related Documents :
6705884 - Evaluation of transected spinal cord regeneration in the rat.
16130024 - Post-traumatic moderate systemic hyperthermia worsens behavioural outcome after spinal ...
16368844 - Doxepin by topical application and intrathecal route in rats.
16183224 - Pain-relieving effects of processed aconiti tuber in cci-neuropathic rats.
1124984 - Nervous system degeneration produced by the industrial solvent methyl n-butyl ketone.
1783094 - Influence of melatonin on rat thyroid, adrenals and testis secretion during the day.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  125     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-18     Completed Date:  1998-06-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1433-45     Citation Subset:  IM    
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Data Bank Information
Bank Name/Acc. No.:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acid Sequence
Animals, Genetically Modified
Body Patterning
COS Cells
Cloning, Molecular
DNA-Binding Proteins*
Drosophila / embryology,  genetics,  physiology*
Drosophila Proteins*
Embryo, Nonmammalian / physiology
Evolution, Molecular
Gene Expression Regulation, Developmental*
Genes, Insect
Insect Proteins / biosynthesis,  metabolism*
Macromolecular Substances
Molecular Sequence Data
Recombinant Proteins / biosynthesis,  chemistry
Sequence Alignment
Sequence Homology, Amino Acid
Signal Transduction
Smad4 Protein
Trans-Activators / biosynthesis*,  chemistry
Transforming Growth Factor beta / metabolism
Tumor Cells, Cultured
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Insect Proteins; 0/Macromolecular Substances; 0/Medea protein, Drosophila; 0/Recombinant Proteins; 0/SMAD4 protein, human; 0/Smad4 Protein; 0/Trans-Activators; 0/Transforming Growth Factor beta; 0/dpp protein, Drosophila

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; ev...
Next Document:  Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm.