Document Detail

Meconium and transitional stools may cause interference with near-infrared spectroscopy measurements of intestinal oxygen saturation in preterm infants.
MedLine Citation:
PMID:  22879046     Owner:  NLM     Status:  MEDLINE    
METHODS: Meconium, transitional, and mature stool samples collected from preterm neonates and older infants (ranging from a few days to weeks in age) were analyzed by a bench-top spectrometer to measure light absorbance in the near infrared range (650-950 nm).
RESULTS: Some meconium and transitional stool samples were noted to have a more marked increase in light absorbance as wavelength decreases towards 650 nm, when compared to more mature stools. When compared to the light absorbance spectra of deoxy-hemoglobin (Hb) and oxy-hemoglobin (HbO(2)), there is a high potential that Hb and HbO(2) may be erroneously calculated, resulting in falsely low GI StO(2).
DISCUSSION: Meconium and green colored transitional stools demonstrate a light absorbance spectra that may interfere with NIRS GI measurements, possibly due to their higher biliverdin content, which exhibits a broad spectral absorption peak at 660 nm. Caution is warranted in interpreting GI StO(2) NIRS results in neonates still passing meconium and transitional stools until NIRS-based tissue oximeters to measure GI StO(2) can compensate for the presence of these stool types.
Alecia Thompson; Paul Benni; Sara Seyhan; Richard Ehrenkranz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  765     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-08-10     Completed Date:  2012-12-11     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-92     Citation Subset:  IM    
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MeSH Terms
Feces / chemistry*
Hemoglobins / metabolism
Infant, Newborn
Infant, Premature / metabolism*
Intestines / metabolism*
Meconium / metabolism*
Oxygen / analysis*,  metabolism*
Spectroscopy, Near-Infrared / methods*
Reg. No./Substance:
0/Hemoglobins; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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