Document Detail

Meconium and transitional stools may cause interference with near-infrared spectroscopy measurements of intestinal oxygen saturation in preterm infants.
MedLine Citation:
PMID:  22879046     Owner:  NLM     Status:  In-Data-Review    
In a pilot study, we found that the NIRS measurements were highly variable and dramatically decreased or disappeared sporadically while monitoring gastro-intestinal (GI) StO(2) on preterm neonates. We hypothesized that the light absorption characteristics of different neonatal and infant stool types may be interfering with NIRS GI measurements. Methods: Meconium, transitional, and mature stool samples collected from preterm neonates and older infants (ranging from a few days to weeks in age) were analyzed by a bench-top spectrometer to measure light absorbance in the near infrared range (650-950 nm). Results: Some meconium and transitional stool samples were noted to have a more marked increase in light absorbance as wavelength decreases towards 650 nm, when compared to more mature stools. When compared to the light absorbance spectra of deoxy-hemoglobin (Hb) and oxy-hemoglobin (HbO(2)), there is a high potential that Hb and HbO(2) may be erroneously calculated, resulting in falsely low GI StO(2). Discussion: Meconium and green colored transitional stools demonstrate a light absorbance spectra that may interfere with NIRS GI measurements, possibly due to their higher biliverdin content, which exhibits a broad spectral absorption peak at 660 nm. Caution is warranted in interpreting GI StO(2) NIRS results in neonates still passing meconium and transitional stools until NIRS-based tissue oximeters to measure GI StO(2) can compensate for the presence of these stool types.
Alecia Thompson; Paul Benni; Sara Seyhan; Richard Ehrenkranz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  765     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-08-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-92     Citation Subset:  IM    
Division of Neonatology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
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