| Meconium and transitional stools may cause interference with near-infrared spectroscopy measurements of intestinal oxygen saturation in preterm infants. | |
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MedLine Citation:
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PMID: 22879046 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In a pilot study, we found that the NIRS measurements were highly variable and dramatically decreased or disappeared sporadically while monitoring gastro-intestinal (GI) StO(2) on preterm neonates. We hypothesized that the light absorption characteristics of different neonatal and infant stool types may be interfering with NIRS GI measurements. Methods: Meconium, transitional, and mature stool samples collected from preterm neonates and older infants (ranging from a few days to weeks in age) were analyzed by a bench-top spectrometer to measure light absorbance in the near infrared range (650-950 nm). Results: Some meconium and transitional stool samples were noted to have a more marked increase in light absorbance as wavelength decreases towards 650 nm, when compared to more mature stools. When compared to the light absorbance spectra of deoxy-hemoglobin (Hb) and oxy-hemoglobin (HbO(2)), there is a high potential that Hb and HbO(2) may be erroneously calculated, resulting in falsely low GI StO(2). Discussion: Meconium and green colored transitional stools demonstrate a light absorbance spectra that may interfere with NIRS GI measurements, possibly due to their higher biliverdin content, which exhibits a broad spectral absorption peak at 660 nm. Caution is warranted in interpreting GI StO(2) NIRS results in neonates still passing meconium and transitional stools until NIRS-based tissue oximeters to measure GI StO(2) can compensate for the presence of these stool types. |
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Authors:
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Alecia Thompson; Paul Benni; Sara Seyhan; Richard Ehrenkranz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 765 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2013 |
Date Detail:
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Created Date: 2012-08-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 287-92 Citation Subset: IM |
Affiliation:
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Division of Neonatology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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