Document Detail

Meconium testing for cocaine metabolite: prevalence, perceptions, and pitfalls.
MedLine Citation:
PMID:  8498426     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We determined the prevalence of prenatal cocaine use in a racially mixed sample of urban and suburban mothers and correlated its use with maternal demographics and newborn measurements. STUDY DESIGN: Meconium from 621 consecutive newborns delivered at two university-affiliated urban hospitals were assayed for benzoylecgonine. Maternal and infant characteristics were linked anonymously with the results. Statistical analysis included t test, Fisher's exact test, Duncan's multiple range analysis, and analysis of covariance, with a value of p < 0.05 considered significant. RESULTS: We found that 3.4% of meconium samples had benzoylecgonine levels exceeding 0.1 micrograms/ml. Its presence was statistically correlated with maternal and neonatal characteristics. A nurse's opinion of cocaine use was correct 22% of the time. CONCLUSIONS: Prenatal cocaine use was statistically associated with multiparity, multigravidity, late-onset and clinic-based prenatal care, public assistance, nonwhite race, and low academic achievement. A nurse's opinion was a poor predictor of maternal cocaine use. Cocaine-exposed infants were significantly smaller, and this correlated best with nonwhite background.
S S Rosengren; D B Longobucco; B A Bernstein; S Fishman; E Cooke; F Boctor; S C Lewis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  168     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-22     Completed Date:  1993-06-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1449-56     Citation Subset:  AIM; IM    
Department of Pediatrics, Saint Francis Hospital and Medical Center, Hartford, Connecticut.
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MeSH Terms
Birth Weight
Cocaine* / analogs & derivatives*,  analysis,  metabolism
Infant, Newborn
Meconium / chemistry*
Pregnancy Complications / epidemiology
Prenatal Care / statistics & numerical data
Sensitivity and Specificity
Substance Abuse Detection / methods*
Substance-Related Disorders / diagnosis*,  epidemiology,  metabolism
Suburban Population
Urban Population
Reg. No./Substance:
50-36-2/Cocaine; 519-09-5/benzoylecgonine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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