| Meconium-stained amniotic fluid across gestation and neonatal acid-base status. | |
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MedLine Citation:
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PMID: 16880305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To estimate whether the acid-base status of neonates born to women with meconium-stained amniotic fluid varies across gestation. METHODS: We carried out a retrospective cohort study of all pregnancies that were complicated by meconium-stained amniotic fluid in 2004. Cases were identified from a perinatal pathology database that contained data on all pregnancies complicated by meconium-stained amniotic fluid. Data abstracted from the charts included gestational age at delivery, umbilical arterial pH, birth weight, and the presence or absence of labor. Cases were stratified according to gestational age at delivery. The distribution of meconium-stained amniotic fluid across gestation was computed. The mean umbilical arterial pH values (with 95% confidence intervals) across gestation were assessed by analysis of variance. RESULTS: The mean umbilical arterial pH in women with meconium-stained amniotic fluid did not differ across gestation. The overall incidence of meconium-stained amniotic fluid was 12.0% (766 of 6,403 deliveries). The rates of meconium-stained amniotic fluid increased from 1.2% at 32 weeks to 100% at 42 weeks. CONCLUSION: The rising incidence of meconium-stained amniotic fluid with gestational age is consistent with the hypothesis that fetal maturation is a major etiologic factor in meconium passage. Also, the lack of variation of mean umbilical arterial pH across gestation suggests that fetal acidemia is not increased when meconium passage occurs earlier in pregnancy rather than at later gestational ages. |
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Authors:
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Yinka Oyelese; Angelina Culin; Cande V Ananth; Lillian M Kaminsky; Anthony Vintzileos; John C Smulian |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 108 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-01 Completed Date: 2006-09-07 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 345-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine, UMDNJ, Robert Wood Johnson Medical School/Robert Wood Johnson University Hospital, New Brunswick, New Jersey 08901-1977, USA. YinkaMD@aol.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid* Cohort Studies Female Gestational Age Humans Hydrogen-Ion Concentration Incidence Infant, Newborn Meconium* New Jersey / epidemiology Obstetric Labor Complications / epidemiology*, etiology Pregnancy Pregnancy Outcome Retrospective Studies Umbilical Arteries |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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