Document Detail

Meconium-stained amniotic fluid across gestation and neonatal acid-base status.
MedLine Citation:
PMID:  16880305     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate whether the acid-base status of neonates born to women with meconium-stained amniotic fluid varies across gestation. METHODS: We carried out a retrospective cohort study of all pregnancies that were complicated by meconium-stained amniotic fluid in 2004. Cases were identified from a perinatal pathology database that contained data on all pregnancies complicated by meconium-stained amniotic fluid. Data abstracted from the charts included gestational age at delivery, umbilical arterial pH, birth weight, and the presence or absence of labor. Cases were stratified according to gestational age at delivery. The distribution of meconium-stained amniotic fluid across gestation was computed. The mean umbilical arterial pH values (with 95% confidence intervals) across gestation were assessed by analysis of variance. RESULTS: The mean umbilical arterial pH in women with meconium-stained amniotic fluid did not differ across gestation. The overall incidence of meconium-stained amniotic fluid was 12.0% (766 of 6,403 deliveries). The rates of meconium-stained amniotic fluid increased from 1.2% at 32 weeks to 100% at 42 weeks. CONCLUSION: The rising incidence of meconium-stained amniotic fluid with gestational age is consistent with the hypothesis that fetal maturation is a major etiologic factor in meconium passage. Also, the lack of variation of mean umbilical arterial pH across gestation suggests that fetal acidemia is not increased when meconium passage occurs earlier in pregnancy rather than at later gestational ages.
Yinka Oyelese; Angelina Culin; Cande V Ananth; Lillian M Kaminsky; Anthony Vintzileos; John C Smulian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  108     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-01     Completed Date:  2006-09-07     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  345-9     Citation Subset:  AIM; IM    
Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine, UMDNJ, Robert Wood Johnson Medical School/Robert Wood Johnson University Hospital, New Brunswick, New Jersey 08901-1977, USA.
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MeSH Terms
Amniotic Fluid*
Cohort Studies
Gestational Age
Hydrogen-Ion Concentration
Infant, Newborn
New Jersey / epidemiology
Obstetric Labor Complications / epidemiology*,  etiology
Pregnancy Outcome
Retrospective Studies
Umbilical Arteries

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