| THE MECONIUM-PLUG SYNDROME AND HIRSCHSPRUNG'S DISEASE. | |
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MedLine Citation:
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PMID: 14246296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A mass of inspissated meconium in the distal colon or rectum is a relatively common cause of neonatal intestinal obstruction. The meconium-plug syndrome is unrelated to cystic fibrosis and meconium ileus. The clinical picture is frequently indistinguishable, without contrast study of the colon, from other forms of mechanical intestinal obstruction requiring laparotomy. A barium enema examination is almost always diagnostic, and use of this procedure usually results in dislodgement and passage of the plug.No single cause for the excessive viscosity and tenaciousness of the obstructive meconium mass has been identified. Previous reports have generally emphasized the normal ganglion-cell content of the colon in affected patients.Two infants are described who fulfilled all criteria for this syndrome but who were not rendered asymptomatic, as normally anticipated, by removal of the plug. Subsequent studies revealed the presence of Hirschsprung's disease in both patients. This diagnosis should be considered when an infant with meconium-plug obstruction of the colon fails to follow the usual satisfactory clinical course after the plug has been passed. |
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Authors:
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D A GILLIS; E B GRANTMYRE |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian Medical Association journal Volume: 92 ISSN: 0008-4409 ISO Abbreviation: Can Med Assoc J Publication Date: 1965 Jan |
Date Detail:
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Created Date: 1965-04-01 Completed Date: 1996-12-01 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 0414110 Medline TA: Can Med Assoc J Country: CANADA |
Other Details:
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Languages: eng Pagination: 225-7 Citation Subset: OM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Barium Sulfate* Colonic Diseases* Colostomy* Infant, Newborn* Infant, Newborn, Diseases* Intestinal Obstruction* Meconium* Megacolon* Radiography* Rectum* |
| Chemical | |
Reg. No./Substance:
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7727-43-7/Barium Sulfate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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