Document Detail


Meconium aspiration syndrome: physiological and inflammatory changes in a newborn piglet model.
MedLine Citation:
PMID:  8367215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to evaluate further the physiological and inflammatory changes of meconium aspiration syndrome (MAS), 25 newborn piglets (1-2 days old, 1.5 +/- 0.4 kg) were studied. Piglets were briefly ventilated with 100% oxygen and then received an intratracheal bolus of 3 mL/kg of a 20% suspension of human meconium. They were then further ventilated, keeping PaCO2 at approximately 40 torr and PaCO2 at 70 torr during 4, 12, 24, and 48 h studies. Pulmonary function studies and tracheal aspirates were obtained at time zero and serially throughout the study. Bronchoalveolar lavage was performed at the end of the study to examine endogenous surfactant function. Control piglets received 3 mL/kg of intratracheal saline and were then ventilated for 48 h at an inspired oxygen concentration and mean airway pressure matched to the meconium treated group (to control for the effects of hyperoxia and barotrauma on the lung). MAS caused acute decreases in gas exchange and dynamic lung compliance, which returned toward baseline by 48 h (P < 0.001, ANOVA). Tracheal aspirate absolute neutrophil count, neutrophil chemotactic activity, albumin, and total protein concentrations also increased significantly over time (P < 0.001). Endogenous surfactant function appeared to be significantly inhibited by the meconium. All variables of lung injury were significantly higher in the meconium group compared to the saline control group over the 48 h study. Newborn piglets provide a clinically relevant model of MAS, demonstrating physiological and inflammatory changes with apparent alterations in endogenous surfactant function. Effective therapies for MAS may require interventions directed at all of these components of lung injury.
Authors:
A M Davey; J D Becker; J M Davis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  16     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-10-06     Completed Date:  1993-10-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics (Neonatology) and the Strong Children's Research Center, University of Rochester School of Medicine.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Bronchoalveolar Lavage Fluid / chemistry,  cytology
Chemotaxis, Leukocyte
Disease Models, Animal*
Humans
Infant, Newborn
Leukocyte Count
Lung / pathology
Meconium Aspiration Syndrome / pathology,  physiopathology*
Neutrophils / pathology,  physiology
Respiratory Mechanics
Swine
Grant Support
ID/Acronym/Agency:
5 T32 HL 07216-15/HL/NHLBI NIH HHS; HL-36543/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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