| Meconium aspiration syndrome: pathophysiology and prevention. | |
| | |
MedLine Citation:
|
PMID: 10612363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Despite the common occurrence of intrauterine meconium passage and resultant meconium aspiration syndrome (MAS), controversies regarding the pathophysiology and use of appropriate preventive strategies abound. METHODS: Databases from MEDLINE, MD Consult, and the Science Citation Index were searched from 1964 to the present to find relevant sources of information. RESULTS AND CONCLUSIONS: Meconium passage occurs by three distinct mechanisms: (1) as a physiologic maturational event, (2) as a response to acute hypoxic events, and (3) as a response to chronic intrauterine hypoxia. Meconium passage might merely be a marker of chronic intrauterine hypoxia or can predispose to aspiration of meconium and resultant inflammatory pneumonitis, surfactant inactivation, and mechanical airway obstruction. Aspiration can occur in utero with fetal gasping, or after birth with the first breaths of life. Many cases of MAS can be prevented by the strategies addressed in this article, but some will occur despite appropriate preventive techniques. There is not enough evidence to support the use of amnioinfusion as a standard of care for all pregnancies complicated by meconium. Pharyngeal suctioning before delivery of the shoulders is an effective preventive intervention, as is the combination of pharyngeal suctioning followed by intubation and tracheal suctioning. Suctioning of the trachea may be done on a selective basis depending on fetal vigor and consistency of meconium. |
| | |
Authors:
|
M C Klingner; J Kruse |
Related Documents
:
|
3325493 - Prevention of pre- and perinatal acquired hearing defects, part i: study of causes. 11057563 - Congenital balloon digits in two neonates caused by constriction rings. 6387613 - Human milk protein and medium-chain triglyceride oil supplementation of human milk: pla... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: The Journal of the American Board of Family Practice / American Board of Family Practice Volume: 12 ISSN: 0893-8652 ISO Abbreviation: J Am Board Fam Pract Publication Date: 1999 Nov-Dec |
Date Detail:
|
Created Date: 2000-01-18 Completed Date: 2000-01-18 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8807505 Medline TA: J Am Board Fam Pract Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 450-66 Citation Subset: IM |
Affiliation:
|
Department of Family and Community Medicine, Southern Illinois University School of Medicine, Quincy Family Practice Program, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Humans Infant, Newborn Meconium Aspiration Syndrome / complications, physiopathology*, prevention & control Persistent Fetal Circulation Syndrome / etiology Pneumonia / etiology, pathology Pneumothorax / etiology Pulmonary Surfactants Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Teaching information mastery: creating informed consumers of medical information.
Next Document: Congestive heart failure clinical outcomes study in a private community medical group.